Date published: 2025-10-7

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DNA pol γ Inhibitors

Santa Cruz Biotechnology now offers a broad range of DNA pol gamma Inhibitors for use in various applications. DNA polymerase gamma (pol gamma) is the primary enzyme responsible for the replication and repair of mitochondrial DNA, making it essential for maintaining mitochondrial function and, by extension, cellular energy production and overall cellular health. DNA pol gamma Inhibitors are crucial tools in scientific research, enabling researchers to study the specific role of this enzyme in mitochondrial DNA replication and how its inhibition can affect mitochondrial integrity and function. By using these inhibitors, scientists can explore the consequences of impaired mitochondrial DNA replication, such as the accumulation of mutations, mitochondrial dysfunction, and the potential impact on cellular metabolism and apoptosis. These inhibitors are widely utilized in studies aimed at understanding the complex interactions between mitochondrial DNA replication and cellular homeostasis, providing insights into the mechanisms that underlie mitochondrial-related diseases and the broader implications of mitochondrial dysfunction in aging and neurodegenerative disorders. The availability of DNA pol gamma Inhibitors has significantly advanced research in fields such as molecular biology, genetics, and biochemistry, offering essential tools for dissecting the intricate processes that govern mitochondrial DNA replication and its role in maintaining cellular health. View detailed information on our available DNA pol gamma Inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

18 β-Glycyrrhetinic Acid

471-53-4sc-205573B
sc-205573
sc-205573A
sc-205573C
sc-205573D
1 g
5 g
10 g
25 g
100 g
$28.00
$54.00
$85.00
$129.00
$313.00
3
(2)

18 β-Glycyrrhetinic Acid acts as a selective inhibitor of DNA polymerase gamma, exhibiting unique binding interactions that disrupt the enzyme's active site. Its structural conformation allows for effective competition with natural substrates, leading to altered enzyme kinetics. This compound's hydrophobic regions facilitate interactions with lipid membranes, potentially influencing cellular localization and stability, thereby affecting mitochondrial DNA replication processes.