Distal-less Activators
The class of Distal-less activators is diverse, reflecting the intricate nature of transcription factor regulation and the indirect methods required to influence such proteins. This class mainly includes compounds that modulate key developmental signaling pathways, such as Wnt/β-catenin, Sonic Hedgehog, and the retinoic acid pathway, which are integral to embryonic development and cellular differentiation processes that govern the expression of genes like Distal-less.
Retinoic acid and its receptor agonists, for instance, play a pivotal role in gene regulation during embryogenesis, affecting the expression of numerous homeobox genes. Similarly, compounds like BIO, which activate the Wnt/β-catenin pathway, and Sonic Hedgehog pathway agonists, such as SAG and Purmorphamine, indirectly influence the expression of Distal-less by modulating the pathways crucial for limb patterning and craniofacial development. Growth factors like EGF and FGF2, and cytokines such as TGF-beta1 and BMP4, also belong to this class, given their roles in cell differentiation and development, which are processes intimately linked with the regulation of homeobox genes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate the expression of various homeobox genes, including Distal-less, through its role in embryonic development and differentiation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
By activating Wnt/β-catenin signaling, these compounds can indirectly influence Distal-less gene expression, a pathway crucial in developmental processes. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $166.00 $421.00 | 27 | |
Sonic Hedgehog pathway activation can indirectly influence Distal-less expression, as this pathway is critical in limb patterning and development. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
Transforming Growth Factor-beta1 is involved in various developmental processes and could indirectly impact Distal-less expression. | ||||||
TTNPB | 71441-28-6 | sc-203303 sc-203303A sc-203303B | 10 mg 25 mg 50 mg | $210.00 $347.00 $640.00 | 20 | |
These agonists bind to retinoic acid receptors, influencing gene expression including potentially that of Distal-less. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Activators of the Sonic Hedgehog pathway, like Purmorphamine, may indirectly impact Distal-less expression. | ||||||