Date published: 2025-9-11

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 41 to 50 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

2-(Trimethylsilyl)ethanol

2916-68-9sc-254114
sc-254114A
1 g
10 g
$28.00
$180.00
(0)

2-(Trimethylsilyl)ethanol acts as a versatile derivatization agent, characterized by its trimethylsilyl group that enhances nucleophilicity and facilitates the formation of stable derivatives. The presence of the silyl moiety significantly alters the polarity and solubility of the compound, promoting selective reactions. Its ability to form silyl ethers allows for improved stability and protection of functional groups, while the steric bulk of the trimethylsilyl group influences reaction kinetics and selectivity in various synthetic pathways.

N,N′-Diisopropyl-O-(4-nitrobenzyl)isourea

2978-11-2sc-253160
1 g
$320.00
(0)

N,N'-Diisopropyl-O-(4-nitrobenzyl)isourea serves as a distinctive derivatization agent, notable for its ability to form stable urea derivatives through strong hydrogen bonding interactions. The nitrobenzyl moiety enhances electron-withdrawing properties, which can modulate reactivity and selectivity in nucleophilic attacks. Its sterically hindered isopropyl groups provide unique steric effects, influencing reaction kinetics and enabling selective derivatization in complex mixtures.

Chloromethanesulfonyl chloride

3518-65-8sc-234333
5 g
$92.00
(0)

Chloromethanesulfonyl chloride is a versatile derivatization agent characterized by its reactivity as an acid halide. It readily engages in nucleophilic substitution reactions, forming sulfonyl derivatives that enhance the polarity and solubility of target compounds. The presence of the chloromethyl group facilitates electrophilic interactions, promoting rapid reaction kinetics. Its ability to selectively modify functional groups allows for tailored derivatization strategies in complex analytical applications.

Chlorotrihexylsilane

3634-67-1sc-234348
5 g
$50.00
(0)

Chlorotrihexylsilane serves as a potent derivatization agent, exhibiting unique reactivity due to its silane structure. It participates in hydrosilylation reactions, enabling the formation of stable siloxane bonds with various nucleophiles. This compound enhances the hydrophobicity of substrates, influencing their interaction with solvents and other phases. Its sterically bulky hexyl groups provide steric protection, allowing for selective modifications in complex mixtures, thus facilitating advanced analytical techniques.

Chlorotriethoxysilane

4667-99-6sc-234347
25 g
$199.00
(0)

Chlorotriethoxysilane acts as an effective derivatization agent, characterized by its ability to form robust siloxane linkages through nucleophilic substitution. Its ethoxy groups enhance solubility and reactivity, promoting interactions with polar substrates. The compound's reactivity is influenced by the presence of the chlorine atom, which facilitates electrophilic attack, leading to selective functionalization. This versatility allows for tailored modifications in various analytical applications, enhancing detection sensitivity and specificity.

Hydrindantin dihydrate

5950-69-6sc-250127
sc-250127A
5 g
50 g
$51.00
$184.00
(1)

Hydrindantin dihydrate serves as a versatile derivatization agent, notable for its ability to form stable adducts through hydrogen bonding and dipole-dipole interactions. Its unique structure allows for selective reactivity with various functional groups, facilitating the formation of derivatives that enhance chromatographic separation. The compound's hydrophilic nature aids in solubilizing hydrophobic analytes, improving their detectability in complex matrices. Its kinetic profile supports rapid reaction rates, making it suitable for efficient analytical workflows.

4-Deoxy-D-glucose

28434-38-0sc-220937
25 mg
$317.00
(0)

4-Deoxy-D-glucose acts as a distinctive derivatization agent, characterized by its ability to engage in specific glycosidic bond formation. This compound exhibits unique reactivity with hydroxyl groups, enabling the creation of tailored derivatives that enhance detection sensitivity in analytical techniques. Its structural features promote selective interactions, allowing for the differentiation of isomers. Additionally, its moderate polarity aids in optimizing solubility and stability of the resulting derivatives, streamlining analytical processes.

Boc-OSu

13139-12-3sc-252501
5 g
$125.00
(0)

Boc-OSu serves as a versatile derivatization agent, notable for its ability to form stable amide bonds through acylation reactions. This compound exhibits a high reactivity towards nucleophiles, particularly amines, facilitating the formation of derivatives that enhance chromatographic separation. Its unique steric properties and hydrophobic character improve the solubility of target analytes, while also promoting selective interactions that can aid in distinguishing between closely related compounds.

(3-Bromopropyl)trichlorosilane

13883-39-1sc-225988
5 ml
$82.00
(0)

(3-Bromopropyl)trichlorosilane is a potent derivatization agent characterized by its ability to introduce silane functionalities onto various substrates. Its reactivity stems from the presence of both bromine and trichlorosilane groups, enabling it to engage in nucleophilic substitution reactions. This compound enhances surface properties through silanization, promoting hydrophobicity and improving adhesion. The unique combination of halogen atoms facilitates selective interactions, making it effective for modifying surfaces and enhancing material compatibility.

Hexachlorodisiloxane

14986-21-1sc-228282
10 g
$140.00
(0)

Hexachlorodisiloxane serves as a versatile derivatization agent, notable for its ability to form siloxane linkages through its reactive chlorosilane groups. This compound exhibits unique reactivity patterns, allowing for the efficient cross-linking of silicate materials. Its high chlorination level promotes strong electrophilic interactions, enabling selective functionalization of surfaces. The resulting modifications can significantly alter physical properties, such as thermal stability and mechanical strength, enhancing material performance in various applications.