Dendrin inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the dendrin protein. Dendrin, also known as ankyrin repeat domain-containing protein 2 (ANKRD2), is a protein that contains multiple ankyrin repeat domains and is primarily expressed in skeletal and cardiac muscles. While the precise function of dendrin is still not fully understood, it is believed to be involved in various cellular processes related to muscle development, sarcomere organization, and gene regulation. Dendrin inhibitors are developed through chemical synthesis and structural optimization techniques, with the primary goal of interacting with specific domains or functional motifs of the dendrin protein to influence its cellular functions.
The design of dendrin inhibitors typically involves creating molecules that can selectively bind to dendrin, potentially disrupting its interactions with other cellular components or interfering with its role in muscle development and gene regulation. By modulating dendrin activity, these inhibitors have the potential to affect processes related to muscle physiology and sarcomere organization, contributing to our understanding of the molecular mechanisms governing muscle development and function. The study of dendrin inhibitors offers valuable insights into the intricate molecular processes underlying muscle biology, providing a deeper understanding of the fundamental processes that govern skeletal and cardiac muscle development and maintenance. This research contributes to our knowledge of basic cell biology and the regulatory networks that control muscle-specific gene expression and muscle structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $82.00 $281.00 | ||
A GABA receptor antagonist, bicuculline can modify neuronal excitability, potentially affecting dendrin expression in neurons. | ||||||
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione | 118876-58-7 | sc-478080 | 5 mg | $70.00 | 1 | |
An AMPA receptor antagonist, NBQX might influence synaptic transmission and could indirectly affect dendrin expression. | ||||||
Kainic acid | 487-79-6 | sc-200454 sc-200454A sc-200454B sc-200454C sc-200454D | 5 mg 25 mg 100 mg 1 g 5 g | $87.00 $370.00 $1377.00 $7803.00 $24970.00 | 12 | |
An agonist for kainate receptors, kainic acid alters neuronal excitability, potentially impacting dendrin expression. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
Another AMPA/kainate receptor antagonist, CNQX can affect glutamate-mediated neurotransmission and possibly dendrin expression. | ||||||
LY 341495 | 201943-63-7 | sc-361244 sc-361244A | 1 mg 10 mg | $89.00 $223.00 | 1 | |
A metabotropic glutamate receptor antagonist, LY341495 can affect neuronal signaling and potentially dendrin expression. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
A calcium channel blocker, nimodipine might influence intracellular signaling pathways, potentially affecting dendrin expression. | ||||||