CYP4F3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
17-ODYA (17-Octadecynoic acid) | 34450-18-5 | sc-200488 sc-200488C sc-200488A sc-200488B | 1 mg 5 mg 10 mg 100 mg | $42.00 $132.00 $214.00 $1438.00 | 9 | |
17-Octadecynoic acid exhibits unique interactions with CYP4F3, primarily through its terminal alkyne group, which can engage in specific hydrogen bonding and steric effects within the enzyme's active site. This structural feature may modulate the enzyme's conformation, influencing substrate binding and catalytic activity. The compound's hydrophobic nature enhances its affinity for lipid environments, potentially altering membrane dynamics and affecting metabolic pathways involving fatty acid oxidation. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole, a known CYP450 inhibitor, can inhibit CYP4F3 activity by binding to its heme iron, thereby blocking its enzymatic function in fatty acid and leukotriene metabolism. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole, an antifungal agent, can inhibit CYP4F3 by interacting with its heme group, thereby disrupting its role in fatty acid oxidation. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Itraconazole, another CYP450 inhibitor, can bind to the heme iron of CYP4F3, inhibiting its enzymatic activity in eicosanoid and fatty acid metabolism. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole, known to inhibit various CYP450 enzymes, can also inhibit CYP4F3 by binding to its active site, thereby reducing its role in metabolizing fatty acids and leukotrienes. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole, while a weaker inhibitor of CYP450 enzymes, can potentially inhibit CYP4F3 activity by interacting with its heme group, affecting its role in lipid metabolism. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton, a 5-lipoxygenase inhibitor, can indirectly inhibit CYP4F3 by reducing the synthesis of leukotrienes, thus potentially decreasing the substrate availability for CYP4F3. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin, a known inhibitor of some CYP450 enzymes, can potentially inhibit CYP4F3, impacting its role in metabolizing fatty acids and eicosanoids. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine, known to inhibit several CYP450 enzymes, can potentially inhibit CYP4F3, thereby affecting its role in eicosanoid and fatty acid metabolism. | ||||||