CYP4AA3 Inhibitors
The chemical class of CYP4AA3 inhibitors comprises a diverse group of compounds primarily used as antifungal agents or selective serotonin reuptake inhibitors (SSRIs). These inhibitors exert their inhibitory effects on CYP4AA3 by either binding to its active site or its heme iron, thereby interfering with its catalytic activity and preventing the metabolism of its substrate molecules.
Clotrimazole, ketoconazole, fluconazole, miconazole, econazole, itraconazole, fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, and escitalopram represent promising candidates for further investigation into CYP4AA3 inhibition. By elucidating the mechanisms underlying CYP4AA3 inhibition and its impact on drug metabolism and toxicity, these inhibitors can provide valuable insights into the development of novel strategies for various diseases. Further research into the pharmacological properties and abilities of these compounds may lead to the discovery of new methods for addressing CYP4AA3-mediated drug metabolism pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole inhibits CYP4AA3 by binding to its active site, thereby blocking its enzymatic activity and preventing the metabolism of its substrate molecules. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole inhibits CYP4AA3 by competitively binding to its heme iron, thereby inhibiting its catalytic activity and preventing the metabolism of its substrates. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole inhibits CYP4AA3 by blocking its active site, interfering with its ability to bind substrates and metabolize them, ultimately inhibiting its enzymatic activity. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole inhibits CYP4AA3 by interfering with its catalytic activity, preventing the metabolism of its substrates, and leading to the accumulation of its target molecules. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole inhibits CYP4AA3 by binding to its active site, blocking its catalytic activity, and thereby inhibiting the metabolism of its substrate molecules. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Itraconazole inhibits CYP4AA3 by binding to its heme iron, competitively inhibiting its enzymatic activity, and preventing the metabolism of its substrate molecules. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Fluoxetine inhibits CYP4AA3 by competitively binding to its active site, blocking its enzymatic activity, and interfering with the metabolism of its substrate molecules. | ||||||
Paroxetine | 61869-08-7 | sc-507527 | 1 g | $180.00 | ||
Paroxetine inhibits CYP4AA3 by interfering with its catalytic activity, blocking its active site, and preventing the metabolism of its substrate molecules. | ||||||
Fluvoxamine | 54739-18-3 | sc-207697 | 25 mg | $315.00 | 1 | |
Fluvoxamine inhibits CYP4AA3 by binding to its heme iron, competitively inhibiting its enzymatic activity, and blocking the metabolism of its substrate molecules. | ||||||
Escitalopram | 128196-01-0 | sc-357349 sc-357349A | 10 mg 50 mg | $128.00 $408.00 | 2 | |
Escitalopram inhibits CYP4AA3 by binding to its heme iron, competitively inhibiting its enzymatic activity, and blocking the metabolism of its substrate molecules. | ||||||