cryptdin 17 Inhibitors
Cryptdin 17 inhibitors are part of a class of antimicrobial peptides known as cryptdins, which are predominantly expressed in the Paneth cells of the intestinal mucosa. These peptides play a crucial role in the innate immune response, contributing to the defense against a variety of pathogens such as bacteria, fungi, and viruses. Cryptdin 17 is characterized by its specific amino acid sequence and structural properties, which grant it a unique ability to interact with microbial membranes. The peptide typically adopts a helical conformation, allowing it to penetrate lipid bilayers effectively and disrupt the integrity of microbial cells. This membrane-disrupting action is a hallmark of many antimicrobial peptides, facilitating the rapid neutralization of potential threats in the gut environment.
Inhibitors of cryptdin 17 can act through several mechanisms that interfere with the peptide's antimicrobial functions. These inhibitors may bind directly to cryptdin 17, preventing it from interacting with target pathogens or altering its conformation in a way that diminishes its efficacy. Furthermore, some inhibitors can affect the properties of microbial membranes, making them less susceptible to disruption by cryptdin 17. By modifying the lipid composition or charge of these membranes, the inhibitors can create an unfavorable environment for the peptide's action. The study of cryptdin 17 inhibitors provides valuable insights into the mechanisms of host defense and microbial adaptation, highlighting the delicate balance between antimicrobial activity and microbial resilience within the gut microbiome. Understanding these interactions is essential for comprehending the complex dynamics of intestinal health and the roles of antimicrobial peptides in maintaining microbial homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a vacuolar ATPase inhibitor that indirectly inhibits cryptdin 17 by disrupting lysosomal acidification. This influences the antimicrobial humoral immune response mediated by antimicrobial peptides. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is a toll-like receptor 7 agonist that indirectly inhibits cryptdin 17 by modulating the innate immune response in mucosa. This influences antimicrobial humoral immune responses against bacteria. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase inhibitor, indirectly inhibiting cryptdin 17 by disrupting PI3K signaling. This impacts the antimicrobial humoral immune response mediated by antimicrobial peptides. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an actin polymerization inhibitor that indirectly inhibits cryptdin 17 by disrupting cytoskeletal dynamics. This influences the innate immune response in mucosa and the response to bacteria. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 mitogen-activated protein kinase (MAPK) inhibitor, indirectly inhibiting cryptdin 17 by modulating the MAPK pathway. This affects the innate immune response in mucosa and the response to bacteria. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist that indirectly inhibits cryptdin 17 by suppressing inflammatory pathways. This influences the antimicrobial humoral immune response mediated by antimicrobial peptides. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that indirectly inhibits cryptdin 17 by modulating mTOR signaling. This impacts the antimicrobial humoral immune response mediated by antimicrobial peptides. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, indirectly inhibiting cryptdin 17 by modulating the JNK signaling pathway. This affects the innate immune response in mucosa and the response to bacteria. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine is an antioxidant that indirectly inhibits cryptdin 17 by scavenging reactive oxygen species. This influences the antimicrobial humoral immune response mediated by antimicrobial peptides. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a Janus kinase 2 (JAK2) inhibitor, indirectly inhibiting cryptdin 17 by modulating JAK-STAT signaling. This affects the innate immune response in mucosa and the response to bacteria. | ||||||