CRSP34_Med27 Inhibitors
Chemical inhibitors of CRSP34_Med27 can functionally impede the protein by targeting various pathways and proteins that are closely linked to its activity within the Mediator complex, which is essential for transcriptional regulation. Triptolide, for instance, inhibits the transcriptional activity of NF-kB, a pathway regulated by CRSP34_Med27. The inhibition of NF-kB can diminish the expression of genes dependent on the Mediator complex, effectively inhibiting CRSP34_Med27's function. Celastrol targets the heat shock transcription factor 1 (HSF1), which is part of the heat shock response involving Mediator complex components. The inhibition of HSF1 by Celastrol leads to reduced activity of the Mediator complex, thus impeding CRSP34_Med27. Curcumin, as another example, inhibits the transcription factor AP-1, indirectly inhibiting CRSP34_Med27 by reducing AP-1 dependent transcription that CRSP34_Med27 helps regulate.
Further, Geldanamycin binds to heat shock protein 90 (Hsp90) and disrupts its function, which is necessary for the transcription factors that associate with the Mediator complex, including CRSP34_Med27. Flavopiridol inhibits cyclin-dependent kinases required for phosphorylation and activation of transcription factors that interact with CRSP34_Med27, thereby inhibiting its function. ICG-001 disrupts the interaction between CREB-binding protein and β-catenin, which is crucial for the transcriptional machinery that CRSP34_Med27 is part of. Sulfasalazine's inhibition of Nrf2 also results in the inhibition of transcriptional processes involving CRSP34_Med27. JQ1's inhibition of BET bromodomains, Silibinin's inhibition of STAT pathways, Sirolimus's inhibition of the mTOR pathway, U0126's inhibition of the MEK/ERK pathway, and LY294002's inhibition of PI3K/Akt signaling all contribute to the functional inhibition of CRSP34_Med27 by targeting different aspects of the transcriptional regulation and signaling pathways that CRSP34_Med27 is known to influence.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit the transcriptional activity of NF-kB, which is a pathway that CRSP34_Med27 can regulate as it is a component of the Mediator complex involved in transcriptional regulation. Inhibition of NF-kB can lead to reduced expression of genes that require the Mediator complex, thus functionally inhibiting CRSP34_Med27. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol inhibits the heat shock transcription factor 1 (HSF1), which impacts the heat shock response that can involve Mediator complex components like CRSP34_Med27. By inhibiting HSF1, celastrol could reduce the activity of the Mediator complex and consequently inhibit CRSP34_Med27. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a known inhibitor of the transcription factor AP-1. CRSP34_Med27, as a part of the Mediator complex, is implicated in the regulation of AP-1 dependent transcription. Therefore, by inhibiting AP-1, curcumin can inhibit the functional activity of CRSP34_Med27 indirectly. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and inhibits its function. Hsp90 is required for the proper function of a number of transcription factors that the Mediator complex, including CRSP34_Med27, coactivates. Inhibition of Hsp90 by geldanamycin can therefore lead to a functional inhibition of CRSP34_Med27. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases (CDKs), which are necessary for the phosphorylation and activation of transcription factors that the Mediator complex, including CRSP34_Med27, interacts with. By inhibiting these CDKs, flavopiridol can inhibit the functional activity of CRSP34_Med27. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine can inhibit the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) which is part of transcriptional regulation involving the Mediator complex and CRSP34_Med27. By inhibiting Nrf2, sulfasalazine can lead to a functional inhibition of CRSP34_Med27. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits the BET family of bromodomain proteins, which regulate gene transcription. CRSP34_Med27, being part of the Mediator complex, is involved in the transcription of genes controlled by BET proteins. Thus, JQ1 can indirectly inhibit the function of CRSP34_Med27 by inhibiting the BET bromodomains. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin has been shown to inhibit STAT3 and STAT1 signaling pathways. The Mediator complex, involving CRSP34_Med27, is crucial for the transcriptional activity of STAT-dependent genes. Therefore, silibinin can functionally inhibit CRSP34_Med27 by inhibiting STAT pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Sirolimus binds and inhibits the mTOR pathway, which can control transcription and the cell cycle, processes that the Mediator complex, including CRSP34_Med27, is involved in. Inhibition of mTOR by sirolimus can result in functional inhibition of CRSP34_Med27. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K/Akt signaling, a pathway that affects transcription and is associated with the Mediator complex activities. Inhibition of PI3K/Akt signaling by LY294002 can lead to functional inhibition of CRSP34_Med27. | ||||||