CREB3L4 Activators
CREB3L4 activators are a set of chemical compounds that indirectly promote the functional activity of the CREB3L4 protein through several distinct biochemical pathways. Forskolin, 8-Br-cAMP, Dibutyryl cAMP, and Rolipram work by augmenting intracellular cAMP levels, either by direct activation of adenylate cyclase or by inhibition of cAMP-degrading phosphodiesterases, thus facilitating the activation of protein kinase A (PKA). The phosphorylation cascade initiated by PKA targets the CREB family of transcription factors, leading to the phosphorylation and subsequent activation of CREB3L4, which enhances its role in gene expression. Similarly, Sildenafil, by inhibiting PDE5, raises cGMP levels that can influence CREB-mediated transcription, and IBMX, which prevents cAMP and cGMP degradation, supports sustained signaling conducive to CREB3L4 activation. Salubrinal, through the inhibition of eIF2α phosphatase, and curcumin, by suppressing NF-κB signaling, create a cellular milieu that indirectly facilitates CREB3L4 activity due to enhanced stress responses or reduced transcriptional repression of CREB-targeted genes.
Additional modulators include Epac activator 007-AM, which activates Epac leading to Rap1-mediated CREB activation, and Lithium chloride, which inhibits GSK-3β, stabilizing CREB and thus promoting CREB3L4 activity. Resveratrol's activation of SIRT1 may also enhance CREB3L4 function by deacetylating and activating CREB. SP600125 contributes by inhibiting JNK, which otherwise phosphorylates and inhibits CREB, thus potentially upregulating CREB3L4 activity by reducing inhibitory phosphorylation. Collectively, these activators, through their targeted effects on signaling molecules and pathways, facilitate the enhancement of CREB3L4-mediated gene transcription, cell stress responses, and other regulatory functions without the need for direct upregulation or activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA (protein kinase A), which can then phosphorylate the transcription factor CREB (cAMP response element-binding protein). Phosphorylated CREB can directly enhance the functional activity of CREB3L4 by promoting its activation and nuclear translocation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, thereby sustaining their action within the cell. The increased levels of cAMP can enhance the phosphorylation of CREB, thus indirectly enhancing the activity of CREB3L4. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This compound is a cell-permeable cAMP analog that activates cAMP-dependent protein kinases (PKA). The activation of PKA can result in the phosphorylation of CREB, which in turn can enhance the activity of CREB3L4 by facilitating its activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which degrades cAMP. By inhibiting PDE4, rolipram increases intracellular cAMP levels, leading to activation of PKA and subsequent phosphorylation of CREB, thereby enhancing CREB3L4 activity. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is an inhibitor of eIF2α phosphatase, leading to an increase in phosphorylated eIF2α, which is known to activate genes with upstream open reading frames such as ATF4. CREB3L4, being a CREB protein, could be indirectly enhanced in its functional activity due to the upregulation of stress-induced signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate and affect the activity of transcription factors. Through this mechanism, SIRT1 activity could lead to the deacetylation and activation of CREB, hence enhancing CREB3L4 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is another cell-permeable cAMP analog that activates PKA. The activation of PKA leads to phosphorylation of CREB, which may enhance the activation and function of CREB3L4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, which can prevent the phosphorylation of CREB. This inhibition can lead to the stabilization and activation of CREB, promoting the activity of CREB3L4. | ||||||