CPS1 Activators
The CPS1 Activators represent a diverse group of chemicals crucial for enhancing the functional activity of carbamoyl phosphate synthetase 1 (CPS1), a pivotal enzyme in the urea cycle. Among these activators, N-Acetyl-L-glutamate emerges as a prominent allosteric activator by binding to the regulatory site of CPS1, promoting its catalytic activity. This binding allosterically enhances the binding of ammonia and bicarbonate to the catalytic site, facilitating the conversion into carbamoyl phosphate. Ornithine and citrulline, key substrates in the urea cycle, directly activate CPS1 by serving as intermediates that ensure a continuous flow of metabolites, contributing to the detoxification of ammonia.
Moreover, arginine, acetyl-CoA, calcium ions, glutamine, ATP, CTP, UTP, and glutamate also function as direct activators by serving as substrates or allosteric regulators that enhance CPS1's catalytic efficiency. These activators directly contribute to the conversion of ammonia and bicarbonate into carbamoyl phosphate, highlighting their individual roles in coordinating metabolic pathways and maintaining nitrogen homeostasis. The involvement of ATP underscores the link between cellular energy status and CPS1 activation, emphasizing the intricate interplay between energy metabolism and nitrogen disposal. In summary, the CPS1 Activators encompass a comprehensive array of chemicals that play distinct roles in enhancing CPS1's functional activity. Their direct influence on the urea cycle ensures efficient nitrogen disposal, showcasing the interconnectedness of cellular signaling, metabolic pathways, and nitrogen metabolism. The precise control exerted by these activators highlights the intricacies of CPS1 regulation, contributing to the overall understanding of nitrogen homeostasis in cellular environments.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-glutamic acid | 1188-37-0 | sc-228659 | 25 g | $72.00 | ||
N-Acetyl-L-glutamate is a direct activator of CPS1 that enhances the functional activity of the protein. It serves as an allosteric activator by binding to the regulatory site of CPS1, promoting the enzyme's catalytic activity. This binding allosterically enhances the binding of ammonia and bicarbonate to the catalytic site, facilitating the conversion into carbamoyl phosphate. | ||||||
Ornithine | 70-26-8 | sc-507552 | 100 mg | $77.00 | ||
Ornithine is a direct activator of CPS1 and a key substrate in the urea cycle. By providing a substrate for CPS1, ornithine enhances the functional activity of the enzyme, promoting the conversion of ammonia and bicarbonate into carbamoyl phosphate. This direct activation ensures the continuous flow of metabolites through the urea cycle, facilitating the detoxification of ammonia. | ||||||
L-Citrulline | 372-75-8 | sc-204784 sc-204784A | 5 g 200 g | $32.00 $240.00 | ||
Citrulline is a direct activator of CPS1, serving as an intermediate substrate in the urea cycle. Its role in enhancing CPS1 activity involves its conversion into arginine, a process that requires the catalytic activity of CPS1. By participating in this cycle, citrulline ensures the continuous flow of substrates through CPS1, directly enhancing the enzyme's functional activity. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
Arginine is a direct activator of CPS1 and a crucial substrate in the urea cycle. It enhances the functional activity of CPS1 by serving as a substrate for the enzyme, facilitating the conversion of ammonia and bicarbonate into carbamoyl phosphate. This direct activation ensures the efficient operation of the urea cycle, contributing to the removal of excess nitrogen in the form of urea. | ||||||
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA is a direct activator of CPS1, influencing the enzyme's functional activity in the urea cycle. It serves as a substrate for CPS1, providing the acetyl group necessary for the synthesis of N-Acetyl-L-glutamate, a known allosteric activator of CPS1. This direct activation ensures the availability of N-Acetyl-L-glutamate, promoting the catalytic activity of CPS1 and facilitating the conversion of ammonia and bicarbonate into carbamoyl phosphate. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions act as direct activators of CPS1 by modulating the enzyme's functional activity. The binding of calcium ions to CPS1 enhances the enzyme's catalytic efficiency, promoting the conversion of ammonia and bicarbonate into carbamoyl phosphate. This direct activation is crucial for the regulation of CPS1 activity, as calcium ions serve as allosteric regulators that optimize enzyme function. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
Glutamine is a direct activator of CPS1, serving as a substrate in the urea cycle. By providing the amide group, glutamine facilitates the conversion of ammonia and bicarbonate into carbamoyl phosphate, directly enhancing CPS1 activity. This direct activation ensures the efficient operation of the urea cycle, contributing to the removal of excess nitrogen in the form of urea. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP acts as a direct activator of CPS1 by serving as a co-substrate for the enzyme. The phosphorylation of ATP by CPS1 enhances the functional activity of the enzyme, directly contributing to the conversion of ammonia and bicarbonate into carbamoyl phosphate. This direct activation ensures the energy-dependent regulation of CPS1 activity, highlighting the link between cellular energy status and nitrogen metabolism. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $88.00 $120.00 | 2 | |
UTP (Uridine triphosphate) acts as a direct activator of CPS1, serving as an allosteric regulator. The binding of UTP enhances the enzyme's catalytic activity, directly contributing to the conversion of ammonia and bicarbonate into carbamoyl phosphate. This direct activation is crucial for the precise regulation of CPS1 activity, ensuring optimal function in the urea cycle. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate is a direct activator of CPS1, serving as a substrate in the urea cycle. By providing the amino group, glutamate facilitates the conversion of ammonia and bicarbonate into carbamoyl phosphate, directly enhancing CPS1 activity. This direct activation ensures the efficient operation of the urea cycle, contributing to the removal of excess nitrogen in the form of urea. | ||||||