CPP32 p11 Activators

CPP32 Activators consist of a diverse array of chemical compounds that can enhance the proteolytic activity of CPP32, an essential executor caspase in the apoptosis pathway. Z-DEVD-FMK, by competitively inhibiting other caspases, can increase the substrate availability for CPP32, thereby augmenting its activity. Similarly, Etoposide and Camptothecin, both DNA-damaging agents, induce apoptosis which entails the activation of CPP32 to dismantle cellular components. Compounds such as Tunicamycin, Thapsigargin, and Brefeldin A stress the endoplasmic reticulum, triggering an apoptotic response that culminates in CPP32 activation. Betulinic Acid and Sulforaphane, through mitochondrial pathway induction, and Arsenic Trioxide, via oxidative stress, also contribute to apoptosis, necessitating the action of CPP32 to execute cell death.

Moreover, Staurosporine, a kinase inhibitor, can initiate apoptosis by a broad mechanism that includes the activation of CPP32. Cycloheximide enhances CPP32 activity by inducing apoptosis due to inhibition of protein synthesis. The incorporation of TRAIL, although a biological ligand, in its synthetic form, directly interacts with death receptors, setting off a cascade that activates CPP32.