Cox-2 Inhibitors
Items 71 to 80 of 107 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Vioxx inhibits COX-2, reducing inflammation and pain. It was withdrawn from the market due to cardiovascular safety concerns. | ||||||
SC236 | 170569-86-5 | sc-222298 sc-222298A | 5 mg 25 mg | $77.00 $304.00 | ||
SC236 is a selective COX-2 inhibitor that demonstrates unique binding characteristics through its ability to form strong π-π stacking interactions with aromatic residues in the enzyme's active site. This compound's structural conformation allows for optimal spatial orientation, enhancing its selectivity. Additionally, SC236's hydrophilic and lipophilic balance influences its solubility and permeability, affecting its interaction kinetics and overall stability in biological systems. | ||||||
Etoricoxib | 202409-33-4 | sc-218446 | 10 mg | $35.00 | 3 | |
Etoricoxib selectively inhibits COX-2, reducing inflammation and pain. It is commonly used to manage conditions like osteoarthritis and rheumatoid arthritis. | ||||||
Lumaricoxib | 220991-20-8 | sc-205736 sc-205736A | 100 mg 250 mg | $140.00 $280.00 | ||
Lumiracoxib is a COX-2 inhibitor used for pain relief and reducing inflammation. It selectively inhibits COX-2, limiting prostaglandin production. | ||||||
Indomethacin Ester, 4-Methoxyphenyl- | 261766-24-9 | sc-221757 | 5 mg | $340.00 | ||
Indomethacin Ester, 4-Methoxyphenyl- exhibits distinctive molecular behavior as a COX-2 inhibitor, characterized by its ability to engage in hydrogen bonding with key amino acid residues within the enzyme's active site. This compound's unique steric configuration facilitates selective interactions, promoting a favorable reaction pathway. Its amphiphilic nature contributes to varied solubility profiles, influencing diffusion rates and interaction dynamics in complex environments. | ||||||
N-(2-Phenylethyl)indomethacin Amide | 261766-32-9 | sc-218925 | 50 mg | $290.00 | ||
N-(2-Phenylethyl)indomethacin Amide demonstrates intriguing molecular characteristics as a COX-2 inhibitor, primarily through its ability to form π-π stacking interactions with aromatic residues in the enzyme's active site. This compound's unique amide linkage enhances its stability and solubility, allowing for effective molecular recognition. Additionally, its conformational flexibility may influence binding affinity and kinetics, providing insights into enzyme modulation mechanisms. | ||||||
COX-1 Inhibitor II | 304913-22-2 | sc-202556 | 25 mg | $195.00 | ||
COX-1 Inhibitor II exhibits distinctive molecular behavior as a COX-2 inhibitor, characterized by its ability to engage in hydrogen bonding with key amino acid side chains within the enzyme's active site. This compound's structural rigidity, combined with its hydrophobic regions, facilitates selective interactions that modulate enzymatic activity. Its reaction kinetics are influenced by steric factors, which may alter the rate of binding and dissociation, offering a deeper understanding of enzyme inhibition dynamics. | ||||||
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole | 443919-96-8 | sc-205108 sc-205108A | 1 mg 5 mg | $90.00 $406.00 | ||
3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole demonstrates unique selectivity as a COX-2 inhibitor through its intricate molecular architecture. The presence of fluorine and methoxy groups enhances electron density, promoting specific interactions with the enzyme's hydrophobic pockets. Its conformational flexibility allows for optimal fit within the active site, influencing binding affinity and inhibition efficiency. | ||||||
2,4,5-Trimethoxybenzaldehyde | 4460-86-0 | sc-238357 sc-238357A | 25 g 100 g | $51.00 $177.00 | ||
2,4,5-Trimethoxybenzaldehyde exhibits intriguing properties as a COX-2 inhibitor, characterized by its electron-rich methoxy substituents that facilitate strong π-π stacking interactions with aromatic residues in the enzyme. The compound's planar structure enhances its ability to engage in hydrophobic interactions, while its aldehyde functional group may participate in hydrogen bonding, further stabilizing the enzyme-inhibitor complex and modulating reaction kinetics effectively. | ||||||
CAY10404 | 340267-36-9 | sc-223860 sc-223860A | 1 mg 5 mg | $36.00 $162.00 | 1 | |
CAY10404 is a selective COX-2 inhibitor distinguished by its unique structural features that promote specific molecular interactions. The presence of halogen substituents enhances its lipophilicity, allowing for effective penetration into lipid membranes. Its rigid conformation supports precise alignment within the active site, optimizing binding affinity. Additionally, the compound's ability to form transient charge-transfer complexes may influence reaction kinetics, providing insights into its mechanistic pathways. | ||||||