CNIH4 Activators
CNIH4 activators, as understood in this context, are compounds that influence ion channel and receptor activities, potentially altering the functional demand or expression of CNIH4. These activators do not bind directly to CNIH4 but affect the cellular pathways and systems with which CNIH4 interacts. For example, the modulation of protein kinase C by PMA can affect the trafficking and regulation of ion channels, potentially enhancing the need for CNIH4 activity. Similarly, compounds that affect the second messenger cAMP, such as Forskolin, can influence ion channel regulation, thereby modulating the demand for CNIH4.
Calcium dynamics play a significant role in the regulation of ion channels, and compounds like Ionomycin, Nifedipine, Verapamil, ω-Conotoxin, and Bay K 8644, which modulate calcium entry into cells, have the potential to affect the regulatory function of CNIH4. Tetrodotoxin, by blocking sodium channels, could also alter cellular excitability and thereby the functional requirement for CNIH4. Capsaicin activates TRPV1, a receptor involved in the sensation of pain and heat, and can affect cellular ionic balance, which might impact CNIH4's regulatory roles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC), which can modulate the trafficking and function of ion channels and receptors, potentially increasing the functional requirement for CNIH4 in the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase, leading to increased cAMP levels, which can regulate the activity of ion channels, potentially modifying the demand for regulatory proteins such as CNIH4. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium concentration, which can influence ion channel activity and possibly the role of CNIH4 in modulating these channels. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
A GABA_A receptor antagonist that by inhibiting this inhibitory receptor, can alter the ionic balance and indirectly necessitate the involvement of regulatory proteins like CNIH4. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
An AMPA receptor antagonist that could modify the functional dynamics of glutamate receptors, thereby potentially affecting the role of CNIH4 in receptor regulation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
A calcium channel blocker that by altering calcium influx, may influence the cellular environment in a way that changes the requirement for CNIH4's regulatory role. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Another calcium channel antagonist that, by modulating the flow of calcium ions, could affect the demand for CNIH4 in maintaining ion channel homeostasis. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
An agonist of the TRPV1 receptor that can affect ion channel activity and thus, potentially, the regulatory function of proteins like CNIH4. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
An inorganic compound that can inhibit calcium channels, affecting ion homeostasis and potentially the regulatory activity of CNIH4. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
A calcium channel activator that by enhancing calcium influx could indirectly necessitate an increased regulatory function of CNIH4 to modulate channel activity. | ||||||