Ces1g Inhibitors
Ces1g inhibitors are a class of compounds that specifically target and inhibit the activity of carboxylesterase 1g (Ces1g), an enzyme belonging to the carboxylesterase family. Ces1g plays a crucial role in lipid metabolism by hydrolyzing ester bonds in a variety of substrates, including fatty acids, cholesterol esters, and other lipid derivatives. This enzyme is involved in the regulation of lipid homeostasis and the processing of esterified compounds within the cell. By inhibiting Ces1g, these compounds disrupt its enzymatic activity, leading to alterations in the breakdown and processing of lipid molecules, which can impact overall metabolic balance.
The mechanism of action for Ces1g inhibitors typically involves binding to the active site of the enzyme, preventing it from interacting with its natural lipid substrates. This inhibition blocks the hydrolysis of ester bonds, leading to a buildup of esterified lipids or altering their normal metabolic pathways. Ces1g inhibitors are widely used in research to study the role of this enzyme in lipid metabolism, energy balance, and its broader implications in biochemical pathways related to fat storage and utilization. By inhibiting Ces1g, researchers can explore how the regulation of lipid metabolism is controlled and how disruptions in this process can affect cellular and physiological functions. This makes Ces1g inhibitors valuable tools for investigating the metabolic and biochemical roles of carboxylesterases in various biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, by mimicking estrogen, could bind to estrogen receptors and downregulate Ces1g expression by altering the transcriptional activity specific to estrogen-responsive genes. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol, a synthetic estrogen, may competitively bind to estrogen receptors and reduce Ces1g transcription by triggering negative feedback loops that typically control hormone levels. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been observed to suppress the transcription of anti-inflammatory response genes and could similarly downregulate Ces1g by inhibiting the transcriptional machinery. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole could decrease Ces1g expression by altering gastric acidity, which may lead to changes in gut-liver signaling and subsequent transcriptional repression of liver enzymes. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin can bind to and activate pregnane X receptors (PXR), leading to a decrease in Ces1g expression by promoting the transcription of PXR target genes that antagonize Ces1g transcription. | ||||||
Chlorpyrifos | 2921-88-2 | sc-217887 | 250 mg | $94.00 | ||
Chlorpyrifos may induce oxidative stress that can lead to the activation of transcriptional repressors, resulting in the downregulation of Ces1g expression. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide may lead to histone modifications that result in chromatin remodeling, thus decreasing the accessibility of Ces1g to transcriptional machinery and reducing its expression. | ||||||
Pentadecafluorooctanoic acid | 335-67-1 | sc-250662 sc-250662A | 5 g 25 g | $50.00 $152.00 | ||
Pentadecafluorooctanoic acid could disrupt lipid metabolism, leading to altered nuclear receptor signaling and the subsequent transcriptional repression of genes like Ces1g involved in fat metabolism. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $57.00 | 2 | |
Bis(2-ethylhexyl) phthalate could interfere with the transcription of Ces1g by mimicking or blocking hormones that are normally involved in the upregulation of this gene during lipid metabolism. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride exposure could lead to the activation of stress response pathways, such as the metal-responsive element-binding transcription factor-1 (MTF-1), which may repress Ces1g expression. | ||||||