Centrin-4 Activators
Cetn4, encoding centrin 4, plays a crucial role in cellular processes involving centriole replication and the mitotic cell cycle. Its predicted functions include binding to G-protein beta/gamma-subunit complexes, calcium ions, and heterotrimeric G-proteins, emphasizing its involvement in signal transduction and centrosome-related activities. Cetn4 is primarily localized in the centriole and ciliary basal body, highlighting its significance in cellular organization and function. As an ortholog to human CETN4P, the pseudogene counterpart, Cetn4 holds evolutionary relevance, potentially contributing to conserved cellular functions. Activation of Cetn4 involves various chemical regulators that directly or indirectly influence its functions. GTP, dopamine, and 6-Bnz-cAMP directly activate Cetn4 by promoting interactions with G-proteins, facilitating G-protein binding and influencing centriole replication and mitotic cell cycle. Forskolin, thapsigargin, and ionomycin modulate cAMP levels, ER stress, and calcium signaling, respectively, directly affecting Cetn4 function. Compounds like taxol indirectly activate Cetn4 by stabilizing microtubules, influencing centriole-related processes. Lithium chloride, a GSK-3β inhibitor, and adenosine, interacting with receptors, directly or indirectly activate Cetn4 by modulating GSK-3β-dependent pathways and adenosine receptor signaling, respectively.
In summary, Cetn4 emerges as a key player in orchestrating cellular processes related to centriole replication and the mitotic cell cycle. The diverse range of activators highlights its adaptability and responsiveness to various cellular cues, underscoring its significance in maintaining cellular integrity and functionality. The intricate interplay of these activators provides a nuanced perspective on Cetn4's versatile involvement in cellular processes, positioning it as a crucial component in the dynamic landscape of cell division and organization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Upregulates Cetn4 by inducing ER stress. Thapsigargin inhibits SERCA, causing ER stress, leading to increased Cetn4 expression. This compound indirectly activates Cetn4 by modulating ER stress pathways, influencing centriole replication and mitotic cell cycle. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Activates Cetn4 through calcium chelation. BAPTA-AM sequesters intracellular calcium, influencing Cetn4's calcium-binding activity. This compound directly promotes Cetn4 function by modulating calcium ion binding and affecting centriole replication and mitotic cell cycle. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Upregulates Cetn4 by inducing calcium influx. Ionophore ionomycin elevates intracellular calcium levels, positively affecting Cetn4 expression. This compound indirectly activates Cetn4 by modulating calcium signaling and influencing centriole replication and mitotic cell cycle. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Indirect activator of Cetn4 via microtubule stabilization. Taxol stabilizes microtubules, indirectly promoting Cetn4 function by influencing centriole replication and mitotic cell cycle. This compound modulates microtubule dynamics, affecting cellular processes linked to Cetn4. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Direct activator of Cetn4 through G-protein beta/gamma-subunit binding. Dopamine interacts with G-proteins, promoting Cetn4's association with G-protein complexes. This compound directly enhances Cetn4 function by facilitating G-protein binding and influencing centriole replication and mitotic cell cycle. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $324.00 | 1 | |
Activates Cetn4 through PKA signaling. 6-Bnz-cAMP stimulates PKA, increasing Cetn4 expression. This compound directly promotes Cetn4 function by modulating cAMP-dependent PKA pathways and influencing centriole replication and mitotic cell cycle. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Upregulates Cetn4 by influencing the EGFR pathway. Gefitinib inhibits EGFR, indirectly affecting Cetn4 expression. This compound indirectly activates Cetn4 by modulating EGFR-dependent pathways, influencing centriole replication and mitotic cell cycle. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Direct activator of Cetn4 via GSK-3β inhibition. Lithium chloride inhibits GSK-3β, positively influencing Cetn4 function. This compound directly enhances Cetn4 activity by modulating GSK-3β-dependent pathways and influencing centriole replication and mitotic cell cycle. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Indirect activator of Cetn4 via adenosine receptors. Adenosine interacts with receptors, indirectly affecting Cetn4 expression. This compound modulates adenosine receptor-dependent pathways, influencing centriole replication and mitotic cell cycle. | ||||||