CDKN3 Activators
The chemical class defined as CDKN3 Activators includes a diverse group of compounds that indirectly influence the activity of Cyclin-dependent kinase inhibitor 3 (CDKN3). This influence is primarily exerted through the modulation of various cellular signaling pathways and processes related to cell cycle regulation, rather than through direct interaction with CDKN3.
Key among these compounds are several cyclin-dependent kinase (CDK) inhibitors, including Roscovitine, Flavopiridol, Olomoucine, and PD0332991 (Palbociclib). These inhibitors target CDKs that are integral to cell cycle progression. By modulating the activity of these kinases, they indirectly influence the regulatory role of CDKN3 in the cell cycle, particularly during the G1 to S phase transition. This indirect modulation is crucial, as CDKN3 is a key player in controlling this phase of the cell cycle. Additionally, compounds like Rapamycin, LY294002, Wortmannin, and Curcumin affect other important signaling pathways, such as mTOR and PI3K/Akt.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. By affecting mTOR signaling, it can impact cell cycle progression and indirectly influence CDKN3's role in this process. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By modulating the PI3K/Akt pathway, it can influence cell cycle regulators, indirectly affecting CDKN3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. Its action on the PI3K/Akt pathway can indirectly affect CDKN3's role in cell cycle control. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple signaling pathways, including PI3K/Akt. Its influence on these pathways can indirectly impact CDKN3 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, a histone deacetylase inhibitor, alters gene expression, potentially affecting CDKN3's role in the cell cycle. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Similar to Vorinostat, Trichostatin A is a histone deacetylase inhibitor that can indirectly influence CDKN3 by altering gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, affecting the Nrf2 pathway, can indirectly influence cell cycle regulation and CDKN3's activity. | ||||||