CaMKIIN1 Activators
CaMKIIN1 activators encompass a range of chemical compounds that influence intracellular signaling pathways to enhance the activity of CaMKIIN1. Forskolin, a direct stimulator of adenylate cyclase, raises cAMP levels, consequently promoting CaMKIIN1 activation due to the kinase's cAMP-dependence. Similarly, IBMX, by inhibiting phosphodiesterases, prevents cAMP degradation, thereby sustaining the kinase's activation state. The ionophore A-23187 raises intracellular calcium, which, through the activation of calmodulin, indirectly enhances CaMKIIN1's activity. Compounds like H-89 indirectly increase CaMKIIN1 activity by inhibiting PKA, which cannegatively regulate CaMKIIN1 through phosphorylation.
Phorbol esters such as PMA, through the activation of PKC, might influence the phosphorylation status of proteins within the same signaling cascades as CaMKIIN1, thereby enhancing its activity. Furthermore, inhibitors of cellular phosphatases like okadaic acid result in a net increase in protein phosphorylation, including potential targets within the CaMKIIN1 pathway, leading to its augmented activity. Additionally, db-cAMP acts as a synthetic analog to cAMP, potentiating the kinase's activity via cAMP-dependent pathways. Calcium channel blockers, such as nifedipine and nitrendipine, may indirectly elevate CaMKIIN1 activity by invoking cellular mechanisms that compensate for inhibited calcium influx, thus maintaining calcium homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels. CaMKIIN1 is a cAMP-dependent protein kinase, which means that the elevated cAMP levels enhance CaMKIIN1's kinase activity by relieving autoinhibition. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases. By preventing cAMP degradation, IBMX indirectly increases the activity of CaMKIIN1 by sustaining higher cAMP concentrations which are essential for CaMKIIN1 activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor, which can lead to the activation of stress-activated protein kinases. This in turn can result in the phosphorylation and activation of CaMKIIN1 as part of the cellular stress response. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A-23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin, which in turn can enhance CaMKIIN1 activity by promoting the activation of calmodulin-dependent kinases. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and thereby enhance the activity of a myriad of proteins, including potentially CaMKIIN1, by altering intracellular signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can lead to increased phosphorylation and activation of CaMKIIN1, as these phosphatases would normally dephosphorylate and deactivate it. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. It enhances CaMKIIN1 activity by mimicking the action of cAMP and activating PKA, which can have downstream effects on CaMKIIN1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can lead to a compensatory upregulation of intracellular calcium signaling pathways, potentially enhancing the activity of CaMKIIN1 as part of this response. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine, another calcium channel blocker, can also cause an upregulation of calcium signaling pathways, indirectly leading to enhanced CaMKIIN1 activity as the cell attempts to maintain calcium homeostasis. | ||||||