C9orf69 Activators
Chemical activators of C9orf69 can initiate various intracellular signaling pathways leading to its activation through different mechanisms. Forskolin, by elevating intracellular cAMP levels, indirectly activates protein kinase A (PKA). The activated PKA can then phosphorylate C9orf69, if it is a substrate for PKA, leading to its activation. Ionomycin increases intracellular calcium concentrations, which can then activate calcium-dependent proteins that may interact with or modulate C9orf69. Similarly, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), another kinase capable of phosphorylating C9orf69 or initiating a cascade that results in its activation. S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, stimulating guanylate cyclase to increase cGMP levels, potentially activating protein kinase G (PKG) that might phosphorylate C9orf69. Hydrogen peroxide serves as a signaling molecule that can lead to the activation of various kinases, possibly impacting C9orf69 activity through oxidative stress pathways.
Further, Anisomycin triggers the MAPK pathway, leading to the activation of stress-activated protein kinases such as JNK and p38, which may phosphorylate and activate C9orf69. Okadaic acid, by inhibiting protein phosphatases, can cause C9orf69 to remain in a phosphorylated and active state. Ouabain, through the inhibition of the Na+/K+-ATPase pump, indirectly raises intracellular calcium levels, which could activate C9orf69. Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump, potentially activating C9orf69 via elevated cytosolic calcium levels. Bryostatin 1 modulates PKC activity, which may result in C9orf69 activation. Dibutyryl-cAMP, a cAMP analog, directly activates PKA, which might then activate C9orf69 through phosphorylation. Calyculin A, a strong inhibitor of protein phosphatases 1 and 2A, can maintain C9orf69 in an activated state by preventing its dephosphorylation. These chemicals, through different pathways and mechanisms, can all contribute to the activation of C9orf69.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels which can activate calcium-dependent proteins. C9orf69, if regulated by calcium-dependent proteins or pathways, experiences activation due to the downstream effects of elevated intracellular calcium. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA directly activates protein kinase C (PKC), which phosphorylates target proteins. C9orf69 is activated by PKC through direct phosphorylation if it is a substrate of PKC or if PKC activation triggers a pathway that leads to the activation of C9orf69. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide which activates guanylate cyclase, increasing cGMP levels. The rise in cGMP can activate PKG, which then could phosphorylate and activate C9orf69 if it is part of the PKG pathway. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide can act as a signaling molecule to activate various kinases through oxidative stress pathways. C9orf69 can be activated as a result of the kinase activity modulated by the presence of hydrogen peroxide if it is sensitive to redox changes. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates the MAPK pathway, which includes stress-activated protein kinases like JNK and p38. C9orf69 undergoes activation through this pathway via phosphorylation by these kinases. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases, maintaining proteins in a phosphorylated state. C9orf69 remains activated by being persistently phosphorylated due to the inhibition of dephosphorylation by okadaic acid. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain inhibits the Na+/K+-ATPase pump, leading to increased intracellular calcium levels. Elevated calcium activates pathways that can result in the activation of C9orf69. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the SERCA pump, causing an increase in cytosolic calcium levels which can activate calcium-dependent kinases that, in turn, activate C9orf69. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a modulator of PKC. It can activate PKC which in turn can phosphorylate and activate C9orf69 if it is within PKC's range of substrates or part of a PKC-dependent pathway. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, directly activates PKA. C9orf69 is activated through phosphorylation by PKA if it is a direct substrate of PKA or involved in a PKA-dependent pathway. | ||||||