C9orf43 Activators

EGCG and curcumin, for example, are known to affect multiple signal transduction pathways, which can lead to changes in the phosphorylation state of proteins, a post-translational modification that often regulates protein function. Resveratrol, by activating SIRT1, alters the acetylation status of proteins, thereby influencing their activity and stability. Sulforaphane and spermidine, through activation of Nrf2 and induction of autophagy, respectively, can bring about changes in protein expression and degradation, thereby modifying protein activity.

Quercetin and genistein, with their capacity to inhibit kinase activity, can affect protein function by altering phosphorylation cascades. Capsaicin's effect on TRPV1 receptors and the subsequent signaling pathways may also modulate protein activities. Compounds like 1,1-Dimethylbiguanide, Hydrochloride and rapamycin, which activate AMPK and inhibit mTOR respectively, have broad effects on cellular metabolism and growth. These changes can cascade down to affect the activity of a wide range of proteins, potentially including those similar to C9orf43. Pioglitazone, as a PPAR-gamma agonist, affects gene transcription, which can alter protein function. Lithium's inhibition of GSK-3β may impact Wnt signaling, affecting protein stability and function within this pathway.