C6orf199 Inhibitors
Adenylate kinase 9 (AK9) belongs to the adenylate kinase family of enzymes, which play a critical role in cellular energy homeostasis. These enzymes catalyze the reversible transfer of phosphate groups from adenosine triphosphate (ATP) to adenosine monophosphate (AMP) to form two molecules of adenosine diphosphate (ADP), a reaction that is crucial for maintaining the balance of cellular adenine nucleotides.AK9 is distinguished by its unique structural features and subcellular localization. Unlike other adenylate kinases that are primarily found in the cytosol, AK9 is localized in the mitochondrial matrix. This localization suggests that AK9 may have a specialized role in regulating the adenine nucleotide composition within the mitochondria, an organelle critical for ATP production through oxidative phosphorylation.
The specific physiological role of AK9 is not as well characterized as other adenylate kinases, but it is believed to be involved in the regulation of nucleotide ratios in mitochondria, which is vital for processes such as energy transfer, metabolic regulation, and mitochondrial biogenesis. By modulating the levels of AMP, ADP, and ATP, AK9 can influence the cellular energy charge and the activation of AMP-activated protein kinase (AMPK), a key energy sensor that regulates metabolic pathways to restore energy balance.Given the importance of mitochondria in energy production and metabolic regulation, AK9 may also play a role in broader cellular functions, such as cell growth, differentiation, and response to metabolic stress. Disruptions in adenylate kinase activity, including that of AK9, could potentially contribute to mitochondrial dysfunction and have been implicated in various pathophysiological conditions, including myopathies and cardiomyopathies.In summary, AK9 is an adenylate kinase isoform with a distinctive mitochondrial localization. It is implicated in the crucial task of maintaining adenine nucleotide balance within mitochondria, thereby influencing cellular energy dynamics and mitochondrial function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
An AMP analog that activates AMP-activated protein kinase (AMPK), AICAR mimics cellular energy depletion, potentially influencing the metabolic context AK9 operates within by altering adenine nucleotide levels. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
An adenosine kinase inhibitor, 5-Iodotubercidin increases intracellular adenosine levels, potentially affecting adenylate kinase activities including AK9 by altering substrate availability. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
A nucleoside analogue that inhibits inosine monophosphate dehydrogenase, Ribavirin can alter nucleotide synthesis and potentially influence AK9 activity indirectly by affecting nucleotide pools. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
An inhibitor of dihydrofolate reductase, Methotrexate affects purine and nucleotide synthesis, potentially impacting the cellular context in which AK9 operates. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
By influencing lysosomal pH and autophagy, Hydroxychloroquine may indirectly affect cellular metabolism and the balance of adenine nucleotides, potentially influencing AK9 activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
An inhibitor of inosine monophosphate dehydrogenase, Mycophenolic Acid can decrease guanine nucleotide synthesis, potentially affecting adenylate kinase activities including AK9 by altering nucleotide availability. | ||||||