Bordetella pertussis toxin subunit S1 Activators
The Bordetella pertussis toxin subunit S1 activators represent a subset within the broader category of bacterial toxins, specifically associated with the pathogenic bacterium Bordetella pertussis. Pertussis toxin is a complex multimeric protein that consists of several subunits, among which the S1 subunit plays a pivotal role in the enzymatic activity of the toxin. The S1 subunit functions as an ADP-ribosyltransferase, catalyzing the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD) to a host cell protein, ultimately disrupting cellular signaling pathways. The activators of the S1 subunit are compounds or factors that modulate its enzymatic activity, potentially influencing the overall toxicity of the pertussis toxin.
At a molecular level, the S1 subunit of pertussis toxin is characterized by its unique structure, consisting of distinct domains responsible for binding to host cell receptors and catalyzing the ADP-ribosylation reaction. The activators of S1 are thought to interact with specific regions of this subunit, either enhancing or modulating its catalytic efficiency. Understanding the mechanisms and structural details of these activators is essential for elucidating the intricate interplay between the toxin and its host cell targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, leading to an increase in intracellular cAMP levels, potentially instigating pathways associated with Bordetella pertussis toxin subunit S1 activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Acts as a phosphodiesterase inhibitor, elevating cAMP levels, which may indirectly trigger signaling pathways associated with the activation of Bordetella pertussis toxin subunit S1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Activates beta-adrenergic receptors, triggering G protein-coupled receptor (GPCR) signaling, potentially contributing to the initiation of pathways associated with Bordetella pertussis toxin subunit S1. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Activates muscarinic acetylcholine receptors, thereby initiating GPCR signaling, which might have implications for the initiation of pathways associated with Bordetella pertussis toxin subunit S1. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Activates adenylyl cyclase, leading to an increase in cAMP levels, potentially initiating signaling pathways associated with Bordetella pertussis toxin subunit S1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calmodulin activator that influences calcium signaling, which may have downstream effects, potentially initiating cellular processes related to Bordetella pertussis toxin subunit S1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA), leading to elevated cytosolic calcium levels, with potential implications for Bordetella pertussis toxin subunit S1 activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Influences calcium signaling and activates Ca^2+/calmodulin-dependent pathways, potentially initiating processes associated with Bordetella pertussis toxin subunit S1 activation. | ||||||