β-synuclein Activators
β-synuclein is a member of the synuclein family of proteins, which also includes α-synuclein and γ-synuclein. All members of this family are characterized by their intrinsically disordered nature, meaning that they do not adopt a fixed three-dimensional structure under physiological conditions. This inherent flexibility allows them to interact with a wide variety of cellular partners and play a role in numerous cellular processes. β-synuclein, in particular, is predominantly expressed in the brain and has been identified in various brain regions, including the neocortex, hippocampus, and cerebellum. Structurally, β-synuclein is a small protein composed of approximately 134 amino acids, and, like its family members, it contains three distinct regions: an N-terminal domain, a central hydrophobic region, and a C-terminal domain.
Activators of β-synuclein refer to molecules that upregulate or promote the activity, expression, or stabilization of this protein. The molecular mechanisms by which these activators operate can vary. Some may bind directly to the protein, modulating its conformation or interactions with other cellular components. Others might influence upstream signaling pathways or transcription factors, indirectly leading to increased β-synuclein levels or activity. The precise structure and nature of these activators can be diverse, ranging from small organic molecules to peptides or even larger protein-based entities. Despite this diversity, what unifies them is their ability to modulate the natural behavior of β-synuclein in a cellular or biochemical context. Given the myriad roles of β-synuclein in cellular physiology, understanding and modulating its activity has been an area of keen scientific interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can influence β-synuclein expression. It plays a role in cell differentiation and might modulate protein expression through its action on retinoic acid receptors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, found in the Coleus plant, may elevate β-synuclein levels. Its effect might be due to the activation of the enzyme adenylyl cyclase, leading to increased cAMP levels and modulation of protein expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, might boost β-synuclein expression. It's a histone deacetylase inhibitor and could influence gene expression by modifying chromatin structure. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many plants, might increase β-synuclein levels. Its potential role might be linked to its antioxidant activity and ability to influence various cellular signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol from green tea, could induce β-synuclein expression. It is known to have multiple biological effects including modulation of signaling pathways that might influence protein expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may elevate β-synuclein levels. Lithium's effect on multiple signaling pathways, especially GSK-3β inhibition, might be the reason for this modulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, might boost β-synuclein expression. Its role could be due to its capability to activate the Nrf2 pathway, which plays a role in protein expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a central nervous system stimulant, could influence β-synuclein levels. The potential mechanism might involve adenosine receptor antagonism, leading to modulation of intracellular signaling. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, commonly used as an anticonvulsant, might increase β-synuclein expression. It is a histone deacetylase inhibitor and might influence gene expression through chromatin modification. | ||||||
6-Hydroxydopamine hydrochloride | 28094-15-7 | sc-203482 | 100 mg | $149.00 | 8 | |
6-OHDA, a neurotoxin, might induce β-synuclein levels. Its mechanism might be related to oxidative stress induction and subsequent cellular response mechanisms. | ||||||