β-Arrestin-2 Activators
Chemicals classified as indirect β-Arrestin-2 activators primarily involve compounds that modulate GPCR activity. These chemicals either act as agonists or antagonists at various GPCRs, influencing the recruitment and activity of β-Arrestin-2. Compounds like Isoproterenol, Carvedilol, and Salmeterol target β-adrenergic receptors. Isoproterenol is a potent agonist, while Carvedilol is known for its unique property of β-Arrestin-2 biased signaling despite being an antagonist. These interactions play a crucial role in cardiovascular functions and are of significant interest in pharmacology. Additionally, Oliceridine and Naloxone, targeting opioid receptors, represent another facet of β-Arrestin-2 modulation.
Oliceridine is a G-protein biased agonist, minimizing β-Arrestin-2 mediated effects, whereas Naloxone is an antagonist that can affect β-Arrestin-2 recruitment. Angiotensin II and PTH (1-34) are peptides that, through their respective receptors, influence β-Arrestin-2 activity, crucial in cardiovascular and bone metabolism pathways. In the realm of central nervous system pharmacology, compounds like Apomorphine, Clozapine, and Lurasidone interact with dopamine and serotonin receptors, influencing β-Arrestin-2 activity as part of their mechanism of action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
β-adrenergic receptor agonist, can promote β-Arrestin-2 recruitment to the receptor. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
β-adrenergic receptor antagonist, known for its β-Arrestin-2 biased signaling. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Non-selective β-adrenergic antagonist, may influence β-Arrestin-2 recruitment. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Long-acting β2-adrenergic agonist, potentially influencing β-Arrestin-2 activity. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
Parathyroid hormone fragment, influences β-Arrestin-2 recruitment in bone cells. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Influences β-Arrestin-2 activity through its receptor interaction in cardiovascular systems. | ||||||
R-(−)-Apomorphine hydrochloride hemihydrate | 41372-20-7 | sc-253341 sc-253341A sc-253341B | 100 mg 250 mg 1 g | $61.00 $98.00 $298.00 | ||
Dopamine receptor agonist, may influence β-Arrestin-2 recruitment and signaling. | ||||||
Naloxone | 465-65-6 | sc-477809 | 200 mg | $306.00 | 5 | |
Opioid antagonist, can affect β-Arrestin-2 activity by modulating opioid receptors. | ||||||