AW555464 Inhibitors
Chemical inhibitors of centrosomal protein 170B employ a variety of mechanisms to disrupt its function in microtubule organization and spindle assembly. Colchicine, for instance, binds to tubulin, preventing its polymerization and thereby destabilizing microtubules. This leads to an indirect inhibition of the centrosomal protein 170B, which relies on the structural integrity of microtubules to perform its cellular functions. Similarly, Nocodazole acts by binding to tubulin and inhibiting its polymerization, which results in the disassembly of microtubules, thus impeding the role of centrosomal protein 170B. Podophyllotoxin and Vinblastine also target tubulin, obstructing microtubule assembly and, consequently, the function of centrosomal protein 170B in maintaining the microtubule network. Vincristine adds to this arsenal by binding to tubulin, specifically inhibiting microtubule assembly required for mitotic spindle formation, and hence, the activity of centrosomal protein 170B in cell division.
Further complicating the microtubule dynamics, Paclitaxel works by stabilizing microtubules in their polymerized state, preventing their disassembly which is necessary for the dynamic reconfiguration during cell cycle progression. This stabilization effectively inhibits centrosomal protein 170B's role in the organization of the spindle apparatus. Eribulin, on the other hand, binds to the growing ends of microtubules, leading to their destabilization and a subsequent block in mitosis, which in turn inhibits the function of centrosomal protein 170B. Griseofulvin disrupts microtubule function by binding to tubulin and inhibiting its polymerization, thereby preventing centrosomal protein 170B from performing its role in centrosome integrity. Combretastatin A4 targets tubulin at the colchicine binding site, disrupting microtubule polymerization and leading to the collapse of the microtubule network essential for centrosomal protein 170B function. Lastly, Monastrol and Kif11 Inhibitor specifically inhibit kinesin-related proteins like Eg5, which are crucial for bipolar spindle formation, thereby preventing centrosomal protein 170B from aiding in correct spindle assembly and cell division processes. Through these diverse mechanisms, the function of centrosomal protein 170B in cell division can be effectively inhibited, underscoring the complexity of cellular machinery and the delicate balance required for its proper function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization by binding to tubulin, a key structural component of microtubules. Centrosomal protein 170B is involved in microtubule organization, and the destabilization of microtubules by Colchicine would inhibit the ability of centrosomal protein 170B to participate in this crucial cellular process, thus functionally inhibiting its role in the organization of microtubules. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. By locking microtubules in a polymerized state, it inhibits the dynamic reorganization required for centrosomal protein 170B to perform its role in microtubule spindle assembly during cell division, thus functionally inhibiting centrosomal protein 170B's activity in cell cycle progression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole binds to tubulin and inhibits its polymerization into microtubules, disrupting microtubule dynamics. This inhibition prevents the proper functioning of centrosomal protein 170B, which relies on intact microtubule networks to aid in cell division and centrosome function, therefore functionally inhibiting centrosomal protein 170B's role in the cell. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly by binding to tubulin, inhibiting the formation of microtubule structures. Given that centrosomal protein 170B is essential for microtubule organization and spindle assembly, Vinblastine's action directly inhibits centrosomal protein 170B’s function in cell division by disrupting the microtubule networks it relies upon. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization, impairing the microtubule assembly. This action inhibits the function of centrosomal protein 170B by preventing the formation and maintenance of the microtubule network, which is essential for centrosomal protein 170B's role in centrosome and spindle function during cell division. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, inhibiting its polymerization. This disrupts the mitotic spindle and inhibits centrosomal protein 170B function by preventing the proper assembly and maintenance of the microtubule network that is necessary for its role in cell division and centrosome integrity. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds to the growing positive ends of microtubules, causing their destabilization and leading to mitotic block. This action inhibits centrosomal protein 170B by preventing the proper assembly of the microtubule spindle apparatus, thus inhibiting the function of centrosomal protein 170B in cell division and centrosome dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a small molecule inhibitor of the kinesin Eg5, which is essential for bipolar spindle formation during mitosis. By inhibiting this kinesin, Monastrol disrupts spindle assembly, which in turn inhibits the function of centrosomal protein 170B by preventing the proper formation of spindle structures that are necessary for its role in cell division. | ||||||