ASPDH Inhibitors
ASPDH inhibitors are a class of chemical compounds that specifically inhibit the activity of ASPDH (aspartate dehydrogenase), an enzyme involved in amino acid metabolism. ASPDH catalyzes the oxidative deamination of aspartate to form oxaloacetate, playing a crucial role in metabolic pathways, particularly in the conversion of amino acids into intermediates that feed into the tricarboxylic acid (TCA) cycle. By inhibiting ASPDH, these compounds interfere with this enzymatic process, effectively reducing the production of oxaloacetate from aspartate. This disruption of the enzyme's function can significantly impact metabolic flux, as aspartate is a key substrate in various biosynthetic pathways, and its metabolism is tightly linked to cellular energy production and nitrogen balance.
Research into ASPDH inhibitors provides valuable insight into the broader role of amino acid metabolism and its regulation within cells. By blocking the action of ASPDH, scientists can study the effects of altered aspartate metabolism on cellular functions, such as energy production, redox balance, and the synthesis of key biomolecules. This class of inhibitors allows for the detailed investigation of how metabolic enzymes like ASPDH contribute to maintaining metabolic homeostasis and how changes in their activity influence broader cellular networks. ASPDH inhibitors serve as important tools in metabolic research, particularly for understanding the integration of amino acid metabolism with central metabolic pathways and their impact on cellular physiology. These studies help clarify the role of ASPDH in various metabolic processes and expand the understanding of enzymatic control within the complex networks of cellular metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Cycloserine | 68-41-7 | sc-221470 sc-221470A sc-221470B sc-221470C | 200 mg 1 g 5 g 25 g | $28.00 $77.00 $142.00 $530.00 | 4 | |
L-Cycloserine is an inhibitor of alanine racemase and D-alanine:D-alanine ligase. By inhibiting these enzymes, it disrupts the synthesis of bacterial cell walls. Since alanine racemase produces D-alanine, a substrate for bacterial cell wall synthesis, and ASPDH is involved in converting L-aspartate to D-aspartate, inhibition of alanine pathways by L-Cycloserine would decrease the availability of D-amino acids, leading to less substrate availability for ASPDH catalysis. | ||||||
Tolcapone | 134308-13-7 | sc-220266 | 10 mg | $167.00 | 1 | |
Gavestinel is a glycine site antagonist at the NMDA receptor. It blocks the receptor's response to glycine, a co-agonist required for glutamate action. ASPDH is part of the metabolic pathway that converts L-aspartate to other amino acids, including glycine. By blocking the glycine receptor, Gavestinel can disrupt the demand for glycine, possibly reducing the metabolic flux through pathways involving ASPDH. | ||||||
D-Aspartic acid | 1783-96-6 | sc-202562 | 1 g | $31.00 | ||
D-Aspartic acid is a competitive inhibitor for many enzymes that use L-aspartate as a substrate. It can bind to the active sites of these enzymes, thus preventing L-aspartate from being metabolized. This competition can inhibit ASPDH activity by occupying its active site and preventing it from converting L-aspartate to D-aspartate. | ||||||
L-Aspartic acid | 56-84-8 | sc-472377A sc-472377 sc-472377B | 25 g 100 g 500 g | $40.00 $33.00 $48.00 | ||
This compound is a substrate analog for aspartate-related enzymes and can competitively inhibit enzymes like ASPDH by binding to the active site in place of L-aspartate, preventing its conversion to D-aspartate. | ||||||
Agmatine sulfate | 2482-00-0 | sc-202920 sc-202920A | 100 mg 500 mg | $70.00 $182.00 | ||
Agmatine is a competitive inhibitor of nitric oxide synthase. It may indirectly affect ASPDH by altering the synthesis of nitric oxide, which can modulate various metabolic pathways, including amino acid metabolism where ASPDH functions. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate is a coenzyme for many enzymatic reactions, including amino acid metabolism. It can bind to the active sites of these enzymes, leading to the formation of a Schiff base and acting as a coenzyme or inhibitor. An excess of pyridoxal phosphate can lead to off-target inhibition of enzymes like ASPDH by forming non-productive complexes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a medication known to intercalate into DNA and alter DNA replication and cell division. While not directly related to amino acid metabolism, chloroquine's broad effects on cellular metabolism could lead to disruptions in cellular homeostasis, potentially affecting enzymes like ASPDH. | ||||||
Hydroxylamine solution | 7803-49-8 | sc-250136 | 100 ml | $72.00 | ||
Hydroxylamine is a chemical that can modify pyridoxal phosphate-dependent enzymes by reacting with the aldehyde group of pyridoxal phosphate, forming a stable oxime and preventing the coenzyme from interacting. | ||||||