Amyloglucosidase Inhibitors
Chemical inhibitors of Amyloglucosidase can effectively block the enzyme's ability to catalyze the hydrolysis of starch into glucose. These inhibitors work by competitively binding to the active site of Amyloglucosidase, a process in which the inhibitor's structure closely resembles that of the enzyme's natural substrates, such as oligosaccharides or glucose. Acarbose, for example, is a compound that can inhibit Amyloglucosidase by mimicking the structure of the starch substrates, thereby obstructing the enzyme's capacity to interact with its actual target. Similarly, Castanospermine and Voglibose function along the same lines, occupying the active site due to their structural similarity to the natural substrates, which prevents the enzyme from catalyzing the breakdown of starch.
Other inhibitors, such as 1-Deoxynojirimycin and Miglitol, also competitively inhibit Amyloglucosidase by binding to its active site, where they are structurally analogous to glucose. This binding hinders the conversion of starch into glucose molecules. Isofagomine, Salbostatin, Deoxymannojirimycin, and Valienamine are additional inhibitors that utilize this competitive mechanism. They fit into the active site of Amyloglucosidase, mimicking the structure of its substrates, thus blocking the pathway for starch to be hydrolyzed. Swainsonine and MDL 25637, on the other hand, act by resembling the transition state of the enzymatic reaction or the structure of oligosaccharides, respectively, effectively inhibiting the function of Amyloglucosidase. These inhibitors collectively demonstrate a range of structural mimicries that allow them to bind competitively to the enzyme's active site, thwarting the normal enzymatic activity of breaking down starch into glucose.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acarbose | 56180-94-0 | sc-203492 sc-203492A | 1 g 5 g | $226.00 $605.00 | 1 | |
Acarbose is an alpha-glucosidase inhibitor that can inhibit Amyloglucosidase by competitively inhibiting the enzyme's active site, thus preventing the hydrolysis of starch into glucose. It does so by mimicking the structure of the substrates of Amyloglucosidase. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine binds to the active site of Amyloglucosidase, blocking the access of the substrate to the catalytic center of the enzyme. This inhibition is competitive as castanospermine structurally resembles the oligosaccharides that Amyloglucosidase typically acts upon. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
1-Deoxynojirimycin inhibits Amyloglucosidase by mimicking the structure of glucose. It occupies the enzyme's active site, thus preventing the binding and subsequent breakdown of starch, leading to a decrease in the production of glucose from starch hydrolysis. | ||||||
Voglibose | 83480-29-9 | sc-204384 sc-204384A | 10 mg 50 mg | $198.00 $681.00 | ||
Voglibose acts as a competitive inhibitor of Amyloglucosidase by occupying the enzyme's active site due to its structural similarity to oligosaccharides. This prevents the enzyme from catalyzing the breakdown of starch into glucose. | ||||||
Miglitol | 72432-03-2 | sc-221943 | 10 mg | $161.00 | 1 | |
Miglitol inhibits Amyloglucosidase by binding to the active site of the enzyme, competitively inhibiting its ability to hydrolyze starch into glucose. Its structure is similar to that of the natural substrates of Amyloglucosidase, making it an effective inhibitor. | ||||||
Isofagomine D-Tartrate | 957230-65-8 | sc-207767 sc-207767A sc-207767C sc-207767B | 5 mg 10 mg 50 mg 25 mg | $387.00 $724.00 $2015.00 $1223.00 | ||
Isofagomine inhibits Amyloglucosidase by competitively binding to its active site. The structure of Isofagomine closely mimics that of the natural substrates of Amyloglucosidase, which prevents the enzyme from binding to its real substrates and performing its function. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits Amyloglucosidase by binding to the active site of the enzyme. This compound mimics the transition state of the hydrolysis reaction that Amyloglucosidase catalyzes, thus preventing the breakdown of starch into glucose by the enzyme. | ||||||