ALS Activators
Insulin-like Growth Factor Binding Protein Acid Labile Subunit (ALS) Activators are a class of molecules that play a crucial role in regulating the availability and activity of insulin-like growth factors (IGFs) within the human body. IGFs are essential for various physiological processes, including cell growth, differentiation, and tissue repair. The function of ALS activators primarily revolves around the modulation of the acid labile subunit (ALS), a component of the ternary complex that consists of IGF, IGF-binding proteins (IGFBPs), and ALS. This ternary complex helps to regulate the circulating levels and bioavailability of IGFs.
ALS activators are involved in enhancing the stability and assembly of the IGF ternary complex by facilitating the binding of ALS to IGFBPs. These activators aid in the formation of a high-molecular-weight complex that helps to sequester IGFs in the bloodstream, thereby extending their half-life and preventing their rapid clearance. This dynamic regulation of IGF bioavailability is critical for controlling cell growth and tissue development, as excessive or uncontrolled IGF activity can lead to abnormal cell proliferation and contribute to various pathological conditions. By promoting the formation of the IGF ternary complex, ALS activators contribute to the precise control of IGF signaling, ensuring that it occurs in a regulated and localized manner within the body.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
Arginine is an amino acid known to stimulate GH release when ingested in adequate quantities. It does so by enhancing the activity of growth hormone-releasing hormone (GHRH) and inhibiting somatostatin, a hormone that suppresses GH. The heightened GH secretion from arginine can indirectly increase the activity of insulin-like growth factor binding protein acid-labile subunit (ALS) by potentially raising IGF-1 levels in the bloodstream. | ||||||
Ornithine | 70-26-8 | sc-507552 | 100 mg | $75.00 | ||
Ornithine is an amino acid that can stimulate GH release, although it may be less potent compared to arginine. It exerts its effects through similar mechanisms as arginine. The elevated GH levels due to ornithine may indirectly activate insulin-like growth factor binding protein acid-labile subunit (ALS) by potentially influencing IGF-1 production, thereby enhancing its activity. | ||||||
Ghrelin (human) | 258279-04-8 | sc-364689 sc-364689A | 0.5 mg 1 mg | $182.00 $292.00 | 3 | |
Ghrelin is a naturally occurring peptide hormone produced by the stomach that binds to GHS-R to stimulate GH release from the pituitary gland. It is often referred to as the "hunger hormone." Elevated GH levels due to ghrelin may indirectly activate insulin-like growth factor binding protein acid-labile subunit (ALS) by potentially increasing IGF-1 levels in the bloodstream. | ||||||
Levodopa | 59-92-7 | sc-205372 sc-205372A | 5 g 25 g | $53.00 $168.00 | 9 | |
L-DOPA is a precursor to dopamine and has the potential to stimulate GH release when administered before exercise. Its mechanism of action involves interactions within the dopaminergic system. The resulting increase in GH secretion may indirectly activate insulin-like growth factor binding protein acid-labile subunit (ALS) by potentially influencing IGF-1 levels, thus enhancing its activity. | ||||||