Aldosterone Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Potassium canrenoate | 2181-04-6 | sc-205812 sc-205812A | 1 g 5 g | $54.00 $131.00 | ||
Potassium canrenoate functions as a potent aldosterone antagonist, characterized by its unique ability to disrupt mineralocorticoid receptor signaling. Its molecular structure allows for selective binding, influencing receptor conformation and downstream gene expression. The compound's hydrophilic nature enhances solubility, facilitating interactions with biological membranes. Additionally, its metabolic pathways involve biotransformation, which can modulate its pharmacokinetics and bioavailability, impacting overall efficacy. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $110.00 $624.00 | 4 | |
Eplerenone selectively binds to aldosterone receptors and blocks the reabsorption of sodium and water, which increases urinary output and decreases blood volume. | ||||||
Canrenone | 976-71-6 | sc-205616 sc-205616A | 1 g 5 g | $94.00 $333.00 | 3 | |
Canrenone is a major active metabolite of spironolactone and acts as an aldosterone antagonist, competing with aldosterone for receptor sites. | ||||||
Drospirenone | 67392-87-4 | sc-218277 | 10 mg | $209.00 | ||
Drospirenone is a synthetic progestin that also possesses anti-mineralocorticoid properties, meaning it works as an aldosterone antagonist. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride works by directly blocking the epithelial sodium channel thereby inhibiting sodium reabsorption in the distal convoluted tubules, promoting the loss of sodium and water and the retention of potassium. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $54.00 | ||
Triamterene is a potassium-sparing diuretic that inhibits the epithelial sodium channel in the late distal tubule and collecting duct. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
ARBs prevent angiotensin II from binding to its receptors, thereby inhibiting aldosterone secretion. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole can inhibit adrenal steroidogenesis, including the production of aldosterone. | ||||||
Metyrapone | 54-36-4 | sc-200597 sc-200597A sc-200597B | 200 mg 500 mg 1 g | $26.00 $57.00 $88.00 | 4 | |
Metyrapone inhibits the enzyme 11-β hydroxylase which is involved in the final steps of aldosterone and cortisol synthesis in the adrenal cortex. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits the enzyme P450scc, blocking the conversion of cholesterol to pregnenolone, which is the first step in the synthesis of all steroid hormones, including aldosterone. | ||||||