AE3 Inhibitors
AE3 inhibitors are chemical compounds that can directly or indirectly influence the function of AE3, a protein involved in the exchange of anions such as chloride and bicarbonate. For instance, inhibitors like Acetazolamide, Omeprazole, and Ouabain can disrupt the bicarbonate and proton gradients, which are essential for the normal function of AE3. Acetazolamide, a potent carbonic anhydrase inhibitor, disrupts the bicarbonate gradient by inhibiting carbonic anhydrase, an enzyme that catalyzes the reaction between carbon dioxide and water to form bicarbonate. Omeprazole, a proton pump inhibitor, disrupts the proton gradient, which is crucial for the bicarbonate transport function of AE3. Ouabain, a specific inhibitor of Na+/K+-ATPase, can disrupt the driving force for many transporters, including AE3, indirectly affecting its function.
Additionally, compounds that affect anion exchange and ion balance can influence the function of AE3. DIDS and SITS are anion exchange inhibitors that directly reduce the activity of AE3 by inhibiting the anion exchange process. Niflumic acid, Furosemide, and Hydrochlorothiazide are inhibitors that disrupt the chloride balance, indirectly affecting the function ofAE3. Niflumic acid is a CLCN2 chloride channel blocker, and Furosemide and Hydrochlorothiazide are diuretics that inhibit the Na-K-2Cl symporter and the Na-Cl symporter, respectively, in different parts of the renal tubule. Probenecid, a uricosuric agent that inhibits the transport of various organic anions, can also indirectly influence the function of AE3. Lastly, Verapamil and Quinidine are inhibitors of calcium and sodium channels respectively. Given that AE3 is involved in cellular processes that are ion-dependent, blocking these channels can indirectly affect its function. Amiloride, a potassium-sparing diuretic that inhibits the epithelial sodium channel (ENaC), can also indirectly affect the functional activity of AE3 by disrupting sodium balance.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $81.00 $177.00 $434.00 $541.00 $883.00 $1479.00 $2244.00 | 1 | |
Acetazolamide is a potent carbonic anhydrase inhibitor. Given that AE3 is a member of the anion exchanger family and plays a role in bicarbonate transport, inhibiting carbonic anhydrase can disrupt the bicarbonate gradient, thereby inhibiting the functional activity of AE3. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid is a nonsteroidal anti-inflammatory drug (NSAID) that also acts as a CLCN2 chloride channel blocker. As AE3 is involved in the exchange of chloride ions, blocking these channels may indirectly affect its function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide is a loop diuretic that inhibits the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. This inhibition can disrupt the chloride balance, indirectly affecting the function of AE3. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
Hydrochlorothiazide is a thiazide diuretic that inhibits the Na-Cl symporter in the distal convoluted tubule. By disrupting the chloride balance, it can indirectly affect the function of AE3. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is a uricosuric agent that inhibits renal tubular reabsorption of urate. It also inhibits the transport of various organic anions, which may indirectly affect the function of AE3. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole is a proton pump inhibitor. Given AE3's role in bicarbonate transport and pH regulation, inhibiting proton pumps can disrupt the proton gradient, thereby affecting the functional activity of AE3. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker. As AE3 is involved in cellular processes that are calcium-dependent, blocking these channels can indirectly affect its function. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain is a specific inhibitor of Na+/K+-ATPase. As this pump establishes the driving force for many transporters, including AE3, inhibition can indirectly affect the function of AE3. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine is a class I antiarrhythmic agent that inhibits voltage-gated sodium channels. Given that sodium balance affects chloride and bicarbonate transport, this can indirectly affect the function of AE3. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is a potassium-sparing diuretic that inhibits the epithelial sodium channel (ENaC). By disrupting sodium balance, it can indirectly affect the functional activity of AE3. | ||||||