Date published: 2025-9-5

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ACSL Inhibitors

Santa Cruz Biotechnology now offers a broad range of ACSL Inhibitors for use in various applications. ACSL inhibitors are specialized compounds that target and inhibit acyl-CoA synthetase long-chain (ACSL) enzymes, which are critical for the activation and metabolism of long-chain fatty acids within cells. These enzymes play a pivotal role in lipid metabolism by catalyzing the conversion of free fatty acids into their active form, acyl-CoA, which is essential for processes such as energy production, membrane synthesis, and the generation of signaling molecules. In scientific research, ACSL inhibitors are invaluable tools for studying the regulation of lipid metabolism and the role of fatty acid activation in various physiological and pathological contexts. Researchers use these inhibitors to explore how the inhibition of ACSL activity impacts cellular lipid profiles, energy homeostasis, and the development of metabolic disorders. By blocking ACSL enzymes, scientists can investigate the downstream effects on fatty acid oxidation, lipid storage, and the synthesis of complex lipids. The availability of high-purity ACSL inhibitors from Santa Cruz Biotechnology ensures that experiments are conducted with precision and reproducibility, yielding reliable data that advance our understanding of lipid biology. These inhibitors are also crucial for developing new experimental models to study the metabolic pathways influenced by ACSL activity and for identifying potential targets for intervention in diseases related to lipid metabolism. View detailed information on our available ACSL Inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Triacsin C Solution in DMSO

76896-80-5sc-200574
sc-200574A
100 µg
1 mg
$149.00
$826.00
14
(1)

Triacsin C Solution in DMSO serves as a potent acyl-CoA synthetase inhibitor, disrupting fatty acid metabolism by selectively binding to the enzyme's active site. Its unique molecular interactions lead to altered lipid profiles, influencing cellular signaling pathways. The compound's solubility in DMSO enhances its bioavailability, while its structural features facilitate specific interactions with lipid bilayers, impacting membrane dynamics and cellular processes. This specificity underscores its role in modulating metabolic pathways.

2-Fluoropalmitic acid

89270-22-4sc-202881
sc-202881A
sc-202881B
sc-202881C
5 mg
10 mg
25 mg
50 mg
$85.00
$156.00
$344.00
$643.00
2
(0)

2-Fluoropalmitic acid acts as a unique acyl-CoA synthetase ligand, exhibiting distinct reactivity due to its fluorinated structure. The presence of the fluorine atom enhances its lipophilicity, promoting efficient membrane penetration and interaction with lipid bilayers. This compound can alter fatty acid elongation and desaturation pathways, influencing lipid composition and cellular energy dynamics. Its kinetic profile suggests rapid incorporation into metabolic pathways, potentially affecting overall lipid metabolism.

Triacsin C, lyophilized

76896-80-5sc-477680
sc-477680A
200 µg
1 mg
$325.00
$900.00
3
(0)

Triacsin C, a potent inhibitor of acyl-CoA synthetase, exhibits remarkable specificity in disrupting fatty acid activation. Its unique structure facilitates strong binding interactions with the enzyme, effectively blocking substrate access. This compound influences lipid metabolism by modulating the flux of fatty acids into metabolic pathways, thereby impacting energy homeostasis. The lyophilized form enhances stability and solubility, allowing for precise studies of its kinetic behavior in biochemical assays.