Date published: 2025-9-21

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Acid Halides

Santa Cruz Biotechnology now offers a broad range of Acid Halides for use in various applications. Acid halides, also known as acyl halides, are a class of organic compounds derived from carboxylic acids by replacing the hydroxyl group (-OH) with a halide group (such as chloride, bromide, or fluoride). These compounds are highly reactive intermediates in organic synthesis due to the electrophilic nature of the carbonyl carbon, which readily undergoes nucleophilic acyl substitution reactions. Acid halides are pivotal in the synthesis of a wide array of chemical compounds, including esters, amides, and anhydrides, making them indispensable in chemical research and industrial processes. In scientific research, acid halides are frequently used to study reaction mechanisms and to develop new synthetic methodologies. Their reactivity also allows for the modification of complex molecules, facilitating the construction of elaborate molecular architectures and the introduction of functional groups that can be further manipulated. Additionally, acid halides play a crucial role in polymer chemistry, where they are used to produce polymers with specific structural and functional properties. Researchers have employed acid halides to explore the synthesis of novel materials, catalysts, and ligands, thereby advancing the fields of materials science, catalysis, and coordination chemistry. The availability of a wide variety of acid halides from Santa Cruz Biotechnology enables researchers to select the appropriate compound for their specific needs, thus driving innovation and discovery in multiple scientific disciplines. View detailed information on our available acid halides by clicking on the product name.

Items 161 to 170 of 374 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4,4-oxy-di-benzoylchloride

7158-32-9sc-267766
25 g
$142.00
(0)

4,4-Oxy-di-benzoylchloride, as an acid halide, showcases remarkable reactivity stemming from its dual benzoyl groups, which enhance electrophilicity and facilitate acylation reactions. The presence of the oxy linkage introduces steric and electronic effects that influence reaction kinetics, allowing for selective interactions with nucleophiles. This compound's unique structure enables it to participate in diverse coupling reactions, making it a versatile intermediate in synthetic organic chemistry.

2,4,6-trifluorobenzene-1-sulfonyl chloride

220239-64-5sc-343469
sc-343469A
1 g
5 g
$69.00
$149.00
(0)

2,4,6-Trifluorobenzene-1-sulfonyl chloride, as an acid halide, exhibits exceptional reactivity due to the presence of trifluoromethyl groups, which significantly enhance its electrophilic character. The strong electron-withdrawing nature of the fluorine atoms increases the compound's susceptibility to nucleophilic attack, leading to rapid acylation processes. Its unique sulfonyl chloride functionality allows for efficient formation of sulfonamides and other derivatives, making it a key player in various synthetic pathways.

4-[(dimethylamino)sulfonyl]benzenesulfonyl chloride

sc-348708
sc-348708A
250 mg
1 g
$197.00
$399.00
(0)

4-[(Dimethylamino)sulfonyl]benzenesulfonyl chloride, as an acid halide, showcases remarkable reactivity attributed to its dual sulfonyl groups, which enhance its electrophilic properties. The dimethylamino substituent contributes to a unique balance of nucleophilicity and electrophilicity, facilitating diverse acylation reactions. This compound's ability to form stable intermediates accelerates reaction kinetics, making it a versatile reagent in synthetic organic chemistry.

ethyl 5-(chlorosulfonyl)-3-methyl-1H-pyrazole-4-carboxylate

sc-353512
sc-353512A
250 mg
1 g
$285.00
$584.00
(0)

Ethyl 5-(chlorosulfonyl)-3-methyl-1H-pyrazole-4-carboxylate, functioning as an acid halide, exhibits distinctive reactivity due to its chlorosulfonyl group, which significantly enhances its electrophilic character. This compound engages in rapid acylation processes, driven by the electron-withdrawing effects of the sulfonyl moiety. Its unique pyrazole framework allows for selective interactions with nucleophiles, promoting efficient formation of various derivatives in synthetic pathways.

2-fluoro-4-sulfamoylbenzene-1-sulfonyl chloride

sc-342721
sc-342721A
250 mg
1 g
$384.00
$818.00
(0)

2-Fluoro-4-sulfamoylbenzene-1-sulfonyl chloride, as an acid halide, showcases remarkable reactivity attributed to its sulfonyl chloride functionality. This compound exhibits a high propensity for nucleophilic attack, facilitated by the electron-withdrawing fluorine and sulfonamide groups, which stabilize the transition state. Its unique aromatic structure allows for regioselective reactions, enabling the formation of diverse sulfonamide derivatives through efficient acylation mechanisms.

5-Trifluoromethyl-2-pyridinesulfonyl Chloride

174485-72-4sc-207051
1 ml
$268.00
(0)

5-Trifluoromethyl-2-pyridinesulfonyl chloride, as an acid halide, exhibits exceptional electrophilic character due to the presence of the trifluoromethyl group, which enhances its reactivity. The compound's pyridine ring contributes to its unique electronic properties, allowing for selective interactions with nucleophiles. Its ability to form stable intermediates during acylation reactions facilitates rapid transformation pathways, making it a versatile reagent in synthetic chemistry.

4-Fluoro-2-methylbenzoyl chloride

21900-43-6sc-261926
sc-261926A
1 g
5 g
$27.00
$63.00
(0)

4-Fluoro-2-methylbenzoyl chloride, as an acid halide, showcases remarkable reactivity stemming from its electron-withdrawing fluorine atom, which increases electrophilicity. The presence of the methyl group adjacent to the carbonyl enhances steric effects, influencing reaction kinetics and selectivity. This compound readily participates in acylation reactions, forming acyl derivatives efficiently, while its unique structure allows for diverse interactions with various nucleophiles, promoting a range of synthetic pathways.

3-Methyl-8-quinolinesulfonyl Chloride

74863-82-4sc-209650
1 g
$400.00
(0)

3-Methyl-8-quinolinesulfonyl chloride, as an acid halide, exhibits distinctive reactivity due to its quinoline ring, which introduces aromatic stabilization and influences nucleophilic attack. The sulfonyl chloride moiety enhances electrophilic character, facilitating rapid acylation reactions. Its unique structure allows for selective interactions with a variety of nucleophiles, leading to diverse synthetic routes. Additionally, the compound's planar geometry promotes effective π-stacking interactions, further impacting reaction dynamics.

3-[(diethylamino)sulfonyl]-4-methylbenzenesulfonyl chloride

sc-345822
sc-345822A
1 g
5 g
$487.00
$1455.00
(0)

3-[(Diethylamino)sulfonyl]-4-methylbenzenesulfonyl chloride, as an acid halide, exhibits notable electrophilicity due to its sulfonyl chloride moiety, which enhances its reactivity towards nucleophiles. The diethylamino group introduces steric hindrance, influencing reaction dynamics and selectivity. This compound's unique structure allows for diverse synthetic transformations, facilitating the formation of complex intermediates and promoting rapid reaction kinetics in various chemical environments.

5-(Chlorosulfonyl)salicylic acid

17243-13-9sc-267892
1 g
$175.00
(0)

5-(Chlorosulfonyl)salicylic acid, functioning as an acid halide, showcases a distinctive reactivity profile attributed to its chlorosulfonyl group, which significantly enhances its electrophilic character. The presence of the hydroxyl group on the aromatic ring allows for intramolecular interactions, potentially stabilizing transition states during nucleophilic attacks. This compound's unique architecture promotes selective reactions, enabling the formation of diverse sulfonamide derivatives and influencing reaction pathways in synthetic chemistry.