Date published: 2025-9-15

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Acid Halides

Santa Cruz Biotechnology now offers a broad range of Acid Halides for use in various applications. Acid halides, also known as acyl halides, are a class of organic compounds derived from carboxylic acids by replacing the hydroxyl group (-OH) with a halide group (such as chloride, bromide, or fluoride). These compounds are highly reactive intermediates in organic synthesis due to the electrophilic nature of the carbonyl carbon, which readily undergoes nucleophilic acyl substitution reactions. Acid halides are pivotal in the synthesis of a wide array of chemical compounds, including esters, amides, and anhydrides, making them indispensable in chemical research and industrial processes. In scientific research, acid halides are frequently used to study reaction mechanisms and to develop new synthetic methodologies. Their reactivity also allows for the modification of complex molecules, facilitating the construction of elaborate molecular architectures and the introduction of functional groups that can be further manipulated. Additionally, acid halides play a crucial role in polymer chemistry, where they are used to produce polymers with specific structural and functional properties. Researchers have employed acid halides to explore the synthesis of novel materials, catalysts, and ligands, thereby advancing the fields of materials science, catalysis, and coordination chemistry. The availability of a wide variety of acid halides from Santa Cruz Biotechnology enables researchers to select the appropriate compound for their specific needs, thus driving innovation and discovery in multiple scientific disciplines. View detailed information on our available acid halides by clicking on the product name.

Items 121 to 130 of 374 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4-(Trifluoromethyl)benzoyl chloride

329-15-7sc-397114
sc-397114A
1 g
5 g
$29.00
$61.00
(0)

4-(Trifluoromethyl)benzoyl chloride is an acid halide characterized by its trifluoromethyl group, which imparts notable electron-withdrawing properties. This feature enhances its electrophilicity, facilitating rapid acylation reactions with nucleophiles. The compound's unique steric and electronic environment can lead to selective reactivity patterns, influencing the formation of specific products. Its high reactivity also allows for participation in diverse synthetic pathways, making it a versatile intermediate in organic chemistry.

Palmitoleoyl Chloride

40426-22-0sc-296021
sc-296021A
100 mg
500 mg
$120.00
$300.00
(0)

Palmitoleoyl chloride is an acid halide distinguished by its long-chain fatty acid structure, which contributes to its unique reactivity profile. The presence of the acyl chloride functional group enhances its ability to engage in nucleophilic acyl substitution, promoting the formation of esters and amides. Its hydrophobic nature influences solubility and interaction with various substrates, while the chain length can affect reaction kinetics, leading to distinct selectivity in synthetic applications.

Methyl 2-(chlorosulphonyl)benzoate

26638-43-7sc-263489
1 g
$41.00
(0)

Methyl 2-(chlorosulphonyl)benzoate is an acid halide characterized by its sulfonyl chloride moiety, which significantly enhances its electrophilicity. This compound readily participates in nucleophilic attack, facilitating the formation of sulfonamides and esters. Its unique structure allows for specific interactions with nucleophiles, influencing reaction rates and selectivity. Additionally, the presence of the aromatic ring contributes to its stability and reactivity under various conditions, making it a versatile intermediate in organic synthesis.

2-Diazo-1-oxo naphthalene-5-sulfonyl chloride

138863-74-8sc-335201
5 g
$525.00
(0)

2-Diazo-1-oxo naphthalene-5-sulfonyl chloride is an acid halide distinguished by its diazo and sulfonyl functionalities, which promote unique reactivity patterns. The diazo group enhances its ability to engage in cycloaddition reactions, while the sulfonyl chloride facilitates nucleophilic substitution. This compound exhibits notable stability in the presence of moisture, yet its reactivity can be finely tuned through solvent choice, influencing the kinetics of subsequent reactions. Its aromatic framework contributes to distinct electronic properties, allowing for selective interactions with various nucleophiles.

Methyl phthaloyl chloride

4397-55-1sc-301155
1 g
$84.00
(0)

Methyl phthaloyl chloride is an acid halide characterized by its unique reactivity stemming from the presence of both carbonyl and halogen functionalities. This compound readily participates in acylation reactions, where its electrophilic carbonyl carbon is highly susceptible to nucleophilic attack. The steric effects of the adjacent phthaloyl group can influence reaction rates and selectivity, while its ability to form stable intermediates enhances its utility in synthetic pathways. Additionally, the compound's polar nature allows for intriguing solvation dynamics, affecting its reactivity in various solvents.

Ethyl chlorooxoacetate

4755-77-5sc-239923
sc-239923A
25 g
100 g
$35.00
$85.00
(0)

Ethyl chlorooxoacetate, as an acid halide, exhibits distinctive reactivity due to its electrophilic carbonyl and halogen atoms. This compound is prone to nucleophilic acyl substitution, where the halogen can facilitate the formation of reactive intermediates. Its unique steric and electronic properties can influence reaction kinetics, leading to varied selectivity in synthetic transformations. Furthermore, the compound's polar characteristics enhance its solubility in organic solvents, impacting its behavior in diverse chemical environments.

Benzyl Chloroformate

501-53-1sc-291952
sc-291952A
25 ml
500 ml
$49.00
$210.00
(0)

Benzyl chloroformate, as an acid halide, showcases remarkable reactivity stemming from its electrophilic carbonyl group and the presence of a chlorine atom. This compound readily participates in nucleophilic acyl substitution reactions, where the chlorine atom can enhance the electrophilicity of the carbonyl, promoting rapid reaction rates. Its unique steric configuration allows for selective interactions with nucleophiles, influencing product distribution. Additionally, the compound's moderate polarity contributes to its solubility in various organic solvents, affecting its reactivity in different chemical contexts.

Coumarin-3-carboxylic acid chloride

3757-06-0sc-337642
1 g
$560.00
(0)

Coumarin-3-carboxylic acid chloride, as an acid halide, exhibits distinctive reactivity due to its electron-withdrawing carboxylic acid moiety and the presence of a chloride substituent. This configuration facilitates efficient nucleophilic attack, leading to the formation of acyl derivatives. The compound's planar structure enhances π-stacking interactions, influencing its behavior in solid-state reactions. Its moderate reactivity allows for controlled transformations, making it a versatile intermediate in synthetic pathways.

5,6-Dihydro-4H-cyclopenta[b]thiophene-2-carbonylchloride

142329-25-7sc-319107
sc-319107A
500 mg
1 g
$306.00
$410.00
(0)

5,6-Dihydro-4H-cyclopenta[b]thiophene-2-carbonylchloride, as an acid halide, showcases unique reactivity stemming from its cyclic thiophene structure, which introduces steric hindrance and electronic effects that influence nucleophilic attack. The presence of the carbonyl chloride group enhances its electrophilicity, promoting rapid acylation reactions. Additionally, its conformational flexibility can lead to diverse reaction pathways, allowing for the formation of various acyl derivatives under mild conditions.

Methyl chlorooxoacetate

5781-53-3sc-250367
sc-250367A
5 g
25 g
$31.00
$165.00
(0)

Methyl chlorooxoacetate, as an acid halide, exhibits distinctive reactivity due to its oxoacetate moiety, which enhances its electrophilic character. The presence of the chloro group facilitates nucleophilic substitution, leading to efficient acylation processes. Its ability to engage in both esterification and acylation reactions allows for versatile synthetic pathways. Furthermore, the compound's polar nature can influence solubility and reactivity in various solvents, impacting reaction kinetics.