ACC Synthase 2 Inhibitors

ACC Synthase 2 Inhibitors belong to a specific chemical class that has garnered attention for its role in modulating a crucial step in the biosynthesis of ethylene, a plant hormone. Ethylene plays a pivotal role in various physiological processes, including fruit ripening, abscission (leaf and fruit drop), and response to environmental stresses. ACC Synthase 2 (ACS2) is an enzyme involved in the production of 1-aminocyclopropane-1-carboxylic acid (ACC), which is a direct precursor to ethylene.

Inhibitors targeting ACS2 specifically aim to regulate ethylene production by impeding the conversion of S-adenosylmethionine (SAM) to ACC, effectively suppressing the ethylene synthesis pathway. These inhibitors typically act through competitive or non-competitive mechanisms, binding to key active sites within the enzyme's structure, thereby interfering with its catalytic activity. By disrupting ethylene biosynthesis at the ACS2 level, these compounds influence various plant processes and responses to environmental cues, contributing to the intricate orchestration of plant growth and development.