ABHD5 Inhibitors

Inhibitors of ABHD5 encompass a variety of chemicals that can interfere with the enzymatic activity of ABHD5 or modulate the pathways in which ABHD5 participates. They achieve this by either directly inhibiting the enzyme or by downregulating the metabolic pathways associated with lipid metabolism. Some inhibitors work by decreasing the levels of intracellular cAMP, which is necessary for the initiation of lipolysis and, by extension, could reduce ABHD5 activity, since ABHD5 is crucial for the mobilization of lipid droplets. Others act as antagonists to PPARs, thereby inhibiting the transcription of genes involved in lipid metabolism and potentially leading to a decrease in ABHD5 expression or activity.