Date published: 2026-3-3

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ABAT Inhibitors

The chemical class known as ABAT inhibitors encompasses a diverse group of organic compounds characterized by their unique molecular structures and their capacity to selectively interact with specific components of the 4-aminobutyrate aminotransferase (ABAT) enzyme. ABAT plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), a significant neurotransmitter in the central nervous system. Inhibiting ABAT is a strategy aimed at understanding and modulating GABAergic signaling within cellular processes. ABAT inhibitors are thoughtfully designed through a combination of rational drug design strategies and empirical experimentation. Researchers employ advanced techniques to engineer the structural attributes of these inhibitors, enabling them to selectively bind to distinct regions of ABAT or its associated partners. This selective binding capacity empowers ABAT inhibitors to modulate the activity of ABAT, thereby influencing the complex molecular processes that ABAT regulates, particularly those related to GABA metabolism.The chemical structures of ABAT inhibitors showcase remarkable diversity, reflecting the intricate nature of ABAT and its multifaceted interactions within cellular pathways. The design of these inhibitors is informed by insights drawn from structural biology, computational modeling, and meticulous biochemical analyses. By rigorously probing the molecular interactions involving ABAT, researchers can strategically design inhibitors with tailored attributes that selectively interfere with ABAT-associated functions. ABAT inhibitors represent essential tools for advancing scientific understanding of GABA metabolism and its implications for cellular processes. By perturbing ABAT-mediated pathways, these inhibitors provide a means to unravel the intricate web of molecular events underlying GABAergic signaling. The development of ABAT inhibitors underscores the ongoing commitment to unraveling the nuanced roles of ABAT in cellular physiology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-2,4-Diaminobutyric Acid, Dihydrochloride

1883-09-6sc-218625
1 g
$106.00
(0)

L-2,4-Diaminobutyric Acid, Dihydrochloride, functions as an acid halide with intriguing reactivity stemming from its dual amine groups. These amines can engage in hydrogen bonding, enhancing solubility and reactivity in various environments. The compound's unique steric arrangement promotes selective interactions with electrophiles, leading to distinct reaction kinetics. Additionally, its ability to stabilize charged intermediates plays a crucial role in influencing reaction pathways and outcomes.

Vigabatrin

60643-86-9sc-204382
sc-204382A
sc-204382B
sc-204382C
10 mg
50 mg
100 mg
1 g
$125.00
$485.00
$650.00
$1015.00
2
(1)

Vigabatrin acts as an acid halide, characterized by its unique ability to irreversibly inhibit the enzyme GABA transaminase. This inhibition alters the balance of neurotransmitters, leading to increased levels of GABA. The compound's structural features facilitate specific interactions with the enzyme's active site, promoting a covalent bond formation that significantly impacts reaction kinetics. Its stability in various pH environments further influences its reactivity and interaction dynamics.

gamma-Acetylenic GABA

57659-38-8sc-295002
sc-295002A
1 mg
5 mg
$200.00
$400.00
(0)

Gamma-Acetylenic GABA functions as an acid halide, distinguished by its selective modulation of GABA metabolism through the inhibition of GABA transaminase. Its unique acetylenic group enhances binding affinity to the enzyme, promoting a stable interaction that alters the enzyme's conformation. This compound exhibits notable reactivity in diverse biochemical environments, influencing metabolic pathways and contributing to its kinetic profile in enzymatic reactions.

S(+)-gamma-Vinyl-GABA

74046-07-4sc-222279
sc-222279A
sc-222279B
sc-222279C
sc-222279D
5 mg
10 mg
50 mg
100 mg
250 mg
$463.00
$733.00
$1756.00
$3126.00
$5207.00
(0)

S(+)-gamma-Vinyl-GABA acts as an acid halide, characterized by its ability to selectively inhibit GABA transaminase, thereby modulating GABA levels. The vinyl group enhances its interaction with the enzyme, leading to a unique stabilization of the enzyme-substrate complex. This compound exhibits distinct kinetic properties, facilitating a competitive inhibition mechanism that alters the dynamics of neurotransmitter metabolism, impacting various biochemical pathways.

Trichloroethylene

79-01-6sc-251310
sc-251310A
500 ml
1 L
$66.00
$110.00
(0)

Trichloroethylene is a compound that has been studied for its potential inhibitory effects on ABAT. It may impact GABA metabolism and related pathways.