Chemicals classified as Teddm2 Inhibitors are not specific to the Teddm2 protein but are thought to act through indirect modulation of various signaling pathways that could impact the function of Teddm2. These compounds affect different kinases and signaling molecules, which are integral to numerous cellular processes. For instance, Genistein and Staurosporine are inhibitors that target tyrosine kinases and protein kinases broadly, respectively, and can alter the phosphorylation status of a wide array of proteins, potentially including Teddm2 if it is phosphorylated as part of its regulation.
Compounds like LY294002, PP2, and PD173074 inhibit specific kinase activities, such as PI3K, Src family kinases, and FGFR tyrosine kinase. These enzymes are part of signaling cascades that regulate cell growth, survival, and differentiation. Inhibitors such as SB431542 and U73122 interfere with TGF-beta signaling and phospholipase C activity, respectively, which are important for cellular communication and response to external stimuli. KN-93, Y-27632, PD98059, and Gö 6983 target CaMKII, ROCK kinase, MEK, and protein kinase C isoforms, respectively, each affecting cellular signaling in a different manner.
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