4930415F15Rik Inhibitors
The chemical class referred to as Spmip7 inhibitors includes a diverse array of compounds that, through their interaction with microtubules, exert indirect effects on the function of the Spmip7 protein. These compounds can be broadly categorized into two groups: microtubule stabilizers and microtubule destabilizers. Stabilizers such as Paclitaxel, Peloruside A, and Laulimalide bind to specific sites on microtubules, promoting polymerization and reducing their dynamic instability. These agents lock microtubules in a polymerized state, which can interfere with proteins like Spmip7 that may rely on the natural dynamics of microtubules for their function.
Conversely, microtubule destabilizers, including Colchicine, Vinblastine, and Nocodazole, interact with tubulin subunits or microtubules to inhibit their polymerization or promote depolymerization. This disruption of microtubule dynamics can inhibit the normal function of Spmip7 if it is dependent on the structural integrity of microtubules or their ability to undergo rapid assembly and disassembly. These compounds act at various stages of the microtubule life cycle, from nucleation and growth to shrinkage and disassembly, impacting the overall cytoskeletal architecture and potentially affecting the function of microtubule-associated proteins such as Spmip7.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules by binding to β-tubulin, promoting polymerization and inhibiting disassembly, which could affect Spmip7's function if it interacts with dynamic microtubules. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin, preventing its polymerization into microtubules, which could disrupt Spmip7's interaction with microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Inhibits microtubule formation by binding to tubulin, which could impair Spmip7's function if it is associated with microtubule assembly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules by binding to β-tubulin, which could alter Spmip7's function if it requires intact microtubules for its activity. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Inhibits microtubule assembly by binding to tubulin, which could disrupt Spmip7's association with microtubules. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Inhibits the growth phase of microtubules without affecting the shortening phase, which could modify the dynamics of microtubules associated with Spmip7. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function by binding to microtubule-associated proteins, which could affect Spmip7 if it is a microtubule-associated protein. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Depolymerizes microtubules, which could indirectly impact Spmip7's function through the destabilization of microtubules. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Stabilizes microtubules against depolymerization, which could affect Spmip7 by altering microtubule dynamics. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Inhibits microtubule polymerization, which could impact Spmip7's role in microtubule-associated processes. | ||||||