2610039C10Rik Inhibitors

The chemical class referred to as Mis18a Inhibitors consists of a series of compounds that can indirectly affect the function of Mis18a by targeting cellular processes and signaling pathways related to kinetochore assembly, microtubule dynamics, and cell cycle regulation. These compounds are diverse and include microtubule stabilizers or destabilizers such as Paclitaxel and Nocodazole, which can impede the proper attachment of kinetochores to microtubules and therefore may influence Mis18a's function in chromosome segregation.

Other compounds in this class target key proteins involved in cell cycle progression and spindle assembly. For instance, Purvalanol A and Roscovitine are cyclin-dependent kinase inhibitors that can arrest cell cycle progression, thereby indirectly affecting the recruitment of Mis18a to the centromere. Similarly, inhibitors like BI 2536 and Alisertib target Polo-like kinase 1 and Aurora A kinase, respectively, both of which are critical for the proper functioning of the spindle and can thereby influence Mis18a's role in the centromere. Inhibition of these kinases can result in impaired spindle assembly and function, potentially affecting the Mis18a-dependent centromere recruitment process.