Y-27632, free base CAS: 146986-50-7
MF: C14H21N3O
MW: 247.34

Y-27632, free base (CAS 146986-50-7)

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备用名: Y-27632, free base is also known as ROCK Inhibitor.
应用; Y-27632, free base is the free base form of Y-27632 dihydrochloride and a novel and specific inhibitor of Rho-associated kinases.
CAS号码: 146986-50-7
纯度: 98%
分子量: 247.34
分子式: C14H21N3O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Y-27632, free base is a novel and specific inhibitor of Rho-associated kinases (p160ROCK). Y-27632, free base is cell permeable and inhibits ROCK-I and ROCK-II (IC50=800 nM) by competing with ATP and on cultured human cells mimics the effects of β-agonists. In Swiss 3T3 cells Y-27632, free base abolished stress fibers but did not affect G1-S phase transition at 10 µM. Y-27632, free base has been used to increase survival of human embryonic stem cells as well as display cardioprotective effects. Y-27632, free base has been observed to act on smooth muscle contractions and myosin phosphorylation by inhibiting agonist induced Ca2+ sensitization as well as K+-induced contractions, in vascular smooth muscle. In rat ascites hepatoma (MM1) cells Y-27632, free base had suppressed, through regulation of focal adhesion and focal adhesion kinase, tumor cell invasion.


参考文献

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物理状态 :
Solid
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C[[email protected]](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N

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PMID: # 33513663  Böhnke, J.|Pinkert, S.|Schmidt, M.|Binder, H.|Bilz, NC.|Jung, M.|Reibetanz, U.|Beling, A.|Rujescu, D.|Claus, C.| et al. 2021. Int J Mol Sci. 22:

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PMID: # 33320570  Ouyang, M.|Qian, Z.|Bu, B.|Jin, Y.|Wang, J.|Zhu, Y.|Liu, L.|Pan, Y.|Deng, L.| et al. 2020. ACS Biomater Sci Eng. 6: 5833-5848.

PMID: # 31381906  Bräutigam, J.|Bischoff, I.|Schürmann, C.|Buchmann, G.|Epah, J.|Fuchs, S.|Heiss, E.|Brandes, RP.|Fürst, R.| et al. 2019. J. Mol. Cell. Cardiol. 135: 97-108.

PMID: # 30626885  Davidson, CD. et al. 2019. Sci Rep. 9: 12.

PMID: # 30508787  Fleischer, S.|Jahnke, HG.|Fritsche, E.|Girard, M.|Robitzki, AA.| et al. 2019. Biosens Bioelectron. 126: 624-631.

PMID: # 31921836  Makowiecka, A.|Malek, N.|Mazurkiewicz, E.|Mrówczyńska, E.|Nowak, D.|Mazur, AJ.| et al. 2019. Front Cell Dev Biol. 7: 304.

PMID: # 33405617  Duan, B.|Xu, C.|Das, S.|Chen, JM.|Butcher, JT.| et al. 2019. ACS Biomater Sci Eng. 5: 1416-1425.

PMID: # 30568232  Choudhary, S.|Ramasundaram, P.|Dziopa, E.|Mannion, C.|Kissin, Y.|Tricoli, L.|Albanese, C.|Lee, W.|Zilberberg, J.| et al. 2018. Sci Rep. 8: 17975.

PMID: # 29143227  Singh, J.|Sharma, K.|Pillai, PP.| et al. 2018. Cytotechnology. 70: 465-477.

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