Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

VAMP-1/2 抗体 (4E240): sc-58309

3.7(3)
寫評論提問

说明书
  • VAMP-1/2抗体(4E240)是小鼠单克隆IgM (kappa轻链),规格为200 µg/ml
  • 针对从human脑匀浆中免疫沉淀的含有突触囊泡的组分
  • 推荐用于 mouse, rat, human, bovine, porcine 和 Xenopus 来源的VAMP-1 and VAMP-2 WB 和 IP检测
  • m-IgGκ BP-HRP是VAMP-1/2 Antibody (4E240) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与VAMP-1/2 Antibody (4E240) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

    快捷链接

    関連項目

    Syntaxin最初被认为是停靠蛋白,但最近被归类为锚定蛋白,它们将自己锚定到细胞膜的细胞质表面。已显示Syntaxin与参与胞吐的各种蛋白质结合,包括VAMP(囊泡相关膜蛋白)、NSF(N-乙基马来酰亚胺敏感因子)、SNAP 25(25kDa突触体相关蛋白)、SNAP(可溶性NSF附着蛋白)和突触结合蛋白。VAMP,也称为突触小泡蛋白,包括VAMP-1和VAMP-2,以及突触结合蛋白,是一种可能起胞吐抑制剂作用的蛋白质,都是囊泡蛋白。SNAP,包括α-和γ-SNAP,是细胞质蛋白,它们与由VAMP、SNAP 25和Syntaxin组成的膜受体复合物结合。SNAP介导NSF的膜结合,这对膜融合反应至关重要。另一种被指定为突触素的蛋白质可能通过与SNAP 25和Syntaxin竞争VAMP结合来调节胞吐作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    VAMP-1/2 抗体 (4E240) 参考文献:

    1. 在鼠神经肌肉接头中,突触素蛋白1/VAMP1在Ca2+引发的神经递质释放中的作用。  |  Liu, Y., et al. 2011. J Physiol. 589: 1603-18. PMID: 21282288
    2. 在颞叶癫痫动物模型中,破伤风毒素的结构和功能底物。  |  Ferecskó, AS., et al. 2015. Brain Struct Funct. 220: 1013-29. PMID: 24442865
    3. 雌激素给药后成熟和发育中的小脑深核中SNAP25、VAMP1和VAMP2的分布。  |  Manca, P., et al. 2014. Neuroscience. 266: 102-15. PMID: 24534378
    4. 在嗜铬细胞瘤细胞分泌多巴胺的过程中,钙调神经磷酸酶/NFAT信号通过PMCA依赖机制抑制Vamp1和Vamp2基因。  |  Kosiorek, M., et al. 2014. PLoS One. 9: e92176. PMID: 24667359
    5. 脊椎动物VAMP1的广泛序列变异表明可能存在肉毒杆菌神经毒素的选择性压力。  |  Peng, L., et al. 2014. PLoS Pathog. 10: e1004177. PMID: 25010769
    6. VAMP2与人类浆细胞分泌抗体有关,并可被其他突触素蛋白替代。  |  Gómez-Jaramillo, L., et al. 2018. Cell Mol Immunol. 15: 353-366. PMID: 27616736
    7. 对破伤风毒素敏感的VAMP2在破伤风神经毒素处理过的神经元中可恢复突触和致密核囊泡的融合。  |  Hoogstraaten, RI., et al. 2020. Sci Rep. 10: 10913. PMID: 32616842
    8. 小鼠卵母细胞中的皮质颗粒胞吐作用需要对破伤风毒素敏感的VAMP。  |  de Paola, M., et al. 2021. Exp Cell Res. 405: 112629. PMID: 34023392
    9. 膜内蛋白酶SPPL2a和SPPL2b可调节特定SNARE蛋白的稳态。  |  Ballin, M., et al. 2023. FEBS J. 290: 2320-2337. PMID: 36047592
    10. 分离并鉴定了双前体Rab和VAMP2受体。  |  Martincic, I., et al. 1997. J Biol Chem. 272: 26991-8. PMID: 9341137

    订购信息

    产品名称产品编号规格价格数量收藏夹

    VAMP-1/2 抗体 (4E240)

    sc-58309
    200 µg/ml
    $316.00

    VAMP-1/2 (4E240): m-IgGκ BP-HRP 套装

    sc-550735
    200 µg Ab; 40 µg BP
    $354.00

    Are there any issues with using sc-58309: VAMP-1/2 (4E240) mouse monoclonal primary antibody on mouse samples?

    Asked by: Cweed
    Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-58309 conjugates.
    Answered by: Technical Support
    Date published: 2017-03-07
    • y_2025, m_8, d_30, h_9CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_58309, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 117ms
    • QUESTIONS, PRODUCT
    Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
    Date published: 2015-07-08
    Rated 3 out of 5 by from Robust band seen in WB using mouse brainRobust band seen in WB using mouse brain tissue extract. -SCBT QC
    Date published: 2015-01-30
    Rated 4 out of 5 by from Bands seen in WB using human brain and ratBands seen in WB using human brain and rat brain tissue extracts. -SCBT QC
    Date published: 2013-12-19
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_58309, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 9ms
    • REVIEWS, PRODUCT
    VAMP-1/2 抗体 (4E240) is rated 3.7 out of 5 by 3.
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_58309, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 117ms
    • REVIEWS, PRODUCT