TCPOBOP CAS: 76150-91-9
MF: C16H8Cl4N2O2
MW: 402.06
The most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents..

TCPOBOP (CAS 76150-91-9)

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备用名: 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
应用; TCPOBOP is the most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
CAS号码: 76150-91-9
纯度: ≥98%
分子量: 402.06
分子式: C16H8Cl4N2O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.


参考文献

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571. R: 40; S: 22-36

用法 :
Store as supplied, at room temperature for up to 1 year.Store solutions at -20°C for up to 3 months.
物理状态 :
Solid
溶解度 :
Soluble in DMSO (5 mg/ml). Insoluble in water.
保存 :
Store at room temperature
熔点 :
155-157° C
沸点 :
444.8° C at 760 mmHg (Predicted)
密度 :
~1.5 g/cm3 (Predicted)
折射率 :
n20D 1.64 (Predicted)
IC50 :
HEK293 : EC5050 = 50 nM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UT7145000
PubChem CID :
MDL 号码 :
MFCD00057368
SMILES :
C1=CC(=CC=C1OC2=C(C=C(C=N2)Cl)Cl)OC3=C(C=C(C=N3)Cl)Cl

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PMID: # 33761883  Goldfarb, CN.|Waxman, DJ.| et al. 2021. BMC Genomics. 22: 212.

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