Suberoyl bis-hydroxamic Acid, an HDAC (histone deacetylase) inhibitor, inhibits HDAC1 (ID50 = 0.25 μM) and HDAC3 (ID50 = 0.3 μM). Suberoyl bis-hydroxamic Acid has been shown to induce differentiation of certain murine cells via blocking of HEXIM1 (hexamethylene bisacetamide) activity. Other experiments have shown Suberoyl bis-hydroxamic Acid to induce apoptosis in proliferative cells via induction of P21, P53, PUMA, and Bax gene expression. Additionally, the compound has been noted to activate Notch 1 signaling, which is associated with antiproliferative and apoptotic effects in certain medullary cells. Additional proteins induced by Suberoyl bis-hydroxamic Acid include caspase-3, poly ADP-ribose polymerase, Bcl-X(L), and Bad whose effects range from cellular growth, senescence and apoptosis.
1. Preston, C.M. and McFarlane, M. 1998. Virology. 249: 418-426. PMID: 9791032
2. Zhuang, Z.G., et al. 2008. Acta Pharmacol. Sin. 29: 1459-1466. PMID: 19026165
3. Ning, L., et al. 2008. Oncologist. 13: 98-104. PMID: 18305053
4. Flis, S., et al. 2009. Biochem. Biophys. Res. Commun. 387: 336-341. PMID: 19596269