Spectinomycin dihydrochloride pentahydrate CAS: 22189-32-8
MF: C14H24N2O7•2HCl•5H2O
MW: 495.35

Spectinomycin dihydrochloride pentahydrate (CAS 22189-32-8)

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备用名: Spectinomycin dihydrochloride pentahydrate is also known as Togamycin.
应用; Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic isolated from Streptomyces spectabilis.
CAS号码: 22189-32-8
纯度: ≥95%
分子量: 495.35
分子式: C14H24N2O72HCl•5H2O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic which is closely related to the aminoglycosides. Gram-positive and gram-negative Gonococcus spp. are reported to exhibit susceptibility to Spectinomycin dihydrochloride pentahydrate. Studies indicate that Spectinomycin dihydrochloride pentahydrate interferes with peptidyl tRNA translocation thereby affecting protein synthesis in susceptible bacteria. Additional reports note that mutations in ribosomal proteins may prevent the binding of Spectinomycin dihydrochloride pentahydrate, thus potentially confering resistence to the compound. Additionally, Eschericia coli is reported to be reversibly inhibitied during growth and division by Spectinomycin dihydrochloride pentahydrate and that variations in bacterial sensitivity may be mediated by differences in ribosomes among different E. coli mutants.


参考文献

1. Anderson, P. 1969. J. Bacteriol. 100: 939-947. PMID: 16559073

2. Suter, T.M., et al. 1997. Antimicrob. Agents Chemother. 41: 1385-1388. PMID: 9174205

3. Thom, G. and Prescott, C.D. 1997. Bioorg. Med. Chem. 5: 1081-1086. PMID: 9222501

4. Thompson, P.R., et al. 1998. J. Biol. Chem. 273: 14788-14795. PMID: 9614079

5. Zimmerman, J.M., et al. 2002. Nucleic Acids Res. 30: 5425-5435. PMID: 12490711

外观 :
Powder
物理状态 :
Solid
来源于 :
Streptomyces sp.
溶解度 :
Soluble in water (50 mg/ml), methanol, DMSO (~11 mg/ml), ethanol (~0.3 mg/ml), and DMF (~2 mg/ml).
保存 :
Store at -20° C
熔点 :
210° C
折射率 :
n20D ~1.59 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
WG7400000
PubChem CID :
默克索引 :
14: 8739
MDL 号码 :
MFCD00150886
EC号码 :
244-554-3
Beilstein 注册 :
5684150

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PMID: # 20370835  Broussolle, V. et al. 2010. FEMS Microbiol. Lett. 306: 177-183.

PMID: # 18978052  Klüsener, S. et al. 2009. J. Bacteriol. 191: 365-374.

PMID: # 18952880  Kouwen, TR. et al. 2008. Appl. Environ. Microbiol. 74: 7536-7545.

PMID: # 18302324  Yan, J. et al. 2008. Biochemistry. 47: 3654-3661.

PMID: # 17959651  Bohne, AV. et al. 2007. Nucleic Acids Res. 35: 7256-7266.

PMID: # 17220233  Zeibell, K. et al. 2007. J. Bacteriol. 189: 2331-2338.

PMID: # 16920705  Schwenkert, S. et al. 2006. J. Biol. Chem. 281: 34227-34238.

PMID: # 7721898  Künstner, P. et al. 1995. J. Biol. Chem. 270: 9651-9654.

PMID: # 32350250  Nat Commun. 11: 2095.

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