Sos SH3 domain inhibitor 抑制剂 CAS: 159088-48-9
MF: C53H91N19O11
MW: 1170.43
A synthetic inhibitor for Sos.

Sos SH3 domain inhibitor 抑制剂 (CAS 159088-48-9)

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备用名: Ras inhibitory peptide; VPPPVPPRRR; SOS-1 (human) (1149-1158)
应用; Sos SH3 domain inhibitor is blocks Sos/GRB2 interaction, preventing Ras activation
CAS号码: 159088-48-9
纯度: ≥97%
分子量: 1170.43
分子式: C53H91N19O11
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Sos SH3 domain inhibitor is a biologically active peptide. The SH3 binding sequence of Sos which blocks Sos/GRB2 interaction, preventing Ras activation via receptor protein tyrosine kinases.


参考文献

1. Goudreau, N., et al., 1994. NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. Nature structural biology. 1(12): 898-907. PMID: 7773779
2. Li, N., et al., 1993. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363(6424): 85-8. PMID: 8479541
3. Vidal, M., et al., 2004. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains. Biochemistry. 43(23): 7336-44. PMID: 15182177
4. Jacquot, Yves., et al., 2007. High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide. Bioorganic & medicinal chemistry. 15(3): 1439-47. PMID: 17113302
5. Ho, Pei-Yin., et al., 2006. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Molecular cancer therapeutics. 5(12): 3130-8. PMID: 17172416

外观 :
Lyophilized powder
物理状态 :
Solid
顺序 :
Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg
溶解度 :
Soluble in water.
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。

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PMID: # 21067705  2011. Microvasc. Res. 81: 135-42.

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