Pyrintegrin enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Pyrintegrin is thought to enhance cell-ECM adhesion and activate integrin signaling. Pyrintegrin increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates.
1. Xu, Yue., et al., 2010. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences of the United States of America. 107(18): 8129-34. PMID: 20406903