Pyrazolylpyrrole ERK 抑制剂 CAS: 933786-58-4
MF: C22H17Cl2FN4O2
MW: 459.30
A potent inhibitor of ERK2.

Pyrazolylpyrrole ERK 抑制剂 (CAS 933786-58-4)

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应用; Pyrazolylpyrrole ERK Inhibitor is a potent inhibitor of ERK2
CAS号码: 933786-58-4
纯度: >98%
分子量: 459.30
分子式: C22H17Cl2FN4O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Pyrazolylpyrrole ERK Inhibitor is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). Inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.


参考文献

1 Junttila, M.R., Li, S., Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008). 2 Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of select

物理状态 :
Solid
溶解度 :
Soluble in 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml), ethanol (~ 5 mg/ml), DMSO (~ 1.5 mg/ml), and DMF (~ 2.5 mg/ml).
保存 :
Store at -20° C
IC50 :
Colo205 cells: IC50 = 0.54 µM
Ki 数据 :
ERK2: Ki= 2 nM; PKA: Ki= 0.39 µM; JNK3: Ki= 4 µM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C1=CC(=CC(=C1)Cl)C2=CNNC2=C3C=C(N=C3)C(=O)NC(CO)C4=CC(=C(C=C4)F)Cl

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