Prostaglandin E2 Ethanolamide CAS: 194935-38-1
MF: C22H37NO5
MW: 395.5
An analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells.

Prostaglandin E2 Ethanolamide (CAS 194935-38-1)

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备用名: Dinoprostone Ethanolamide; PGE2-EA; Prostamide E2
应用; Prostaglandin E2 Ethanolamide is an analog of PGE2 shown to bind EP1,2,3, &4 receptors and induce apoptosis in CRC cells
CAS号码: 194935-38-1
分子量: 395.5
分子式: C22H37NO5
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Prostaglandin E2 Ethanolamide is an analog of PGE2 (sc-201225) with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide (sc-200790; N-arachidonoylethanolamide), the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.


参考文献

1. Yu, M., et al. 1997. J. Biol. Chem. 272: 21181-21186. PMID: 9261124
2. Ross, R.A., et al. 2002. J. Pharmacol. Exp. Ther. 301: 900-907. PMID: 12023517
3. Weber, A., et al. 2004. J. Lipid Res. 45: 757-763. PMID: 14729864
4. Patsos, H.A., et al. 2005. Gut. 54: 1741-1750. PMID: 16099783
5. Glass, M., et al. 2005. J. Lipid Res. 46: 1364-1368. PMID: 15863842
6. Correa, F., et al. 2008. Biochem. J. 409: 761-770. PMID: 17961121

物理状态 :
Solid
保存 :
Store at -20° C
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](CC(=O)[[email protected]@H]1C/C=C\\CCCC(=O)NCCO)O)O

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