PPACK dihydrochloride CAS: 142036-63-3
MF: C21H31ClN6O3•2HCl
MW: 523.88

PPACK dihydrochloride (CAS 142036-63-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 96ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
PPACK dihydrochloride is rated 5.0 out of 5 by 3.
loading
5
3
4
0
3
0
2
0
1
0
备用名: PPACK dihydrochloride is also known as D-Phe-Pro-Arg-CMK.
应用; PPACK dihydrochloride is an irreversible, potent, selective inhibitor of thrombin and its downstream effects.
CAS号码: 142036-63-3
分子量: 523.88
分子式: C21H31ClN6O32HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
loading

PPACK dihydrochloride is known to be an irreversible and potent inhibitor of thrombin. PPACK dihydrochloride is shown to inhibit thrombin activation of progelatinase A. In vivo pretreatment with PPACK dihydrochloride has been shown to inhibit thrombin-induced cerebral thromboembolism. PPACK dihydrochloride is also known to act as an anticoagulant in platelet-rich plasma. PPACK dihydrochloride is also known as D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, D-Phe-Pro-Arg-CMK, and D-Phe-Pro-Arg-chloromethylketone.


参考文献

1. Liu, J.T. 1994. Eur. J. Pharmacol. 264(2): 183-190. PMID: 7851481 2. Rahr, H.B. 1994. Thromb. Res. 73(5): 279-284. PMID: 8016814 3. Zucker, S. 1995. J. Biol. Chem. 270(40): 23730-23738. PMID: 7559545 4. Kereiakes, D.J. 2001. J. Thromb. Thrombolysis. 12

物理状态 :
Solid
顺序 :
D-Phe-Pro-Arg-chloromethylketone
溶解度 :
Soluble in water (0.3 mg/ml at 25° C).
保存 :
Store at -20° C
折射率 :
n20D 1.64
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]@H](CC2=CC=CC=C2)N)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

PPACK dihydrochloride (CAS 142036-63-3)  产品相关文献索引

看其他用户如何应用PPACK dihydrochloride (CAS 142036-63-3).点击进入浏览PubMed条目 .

引用1 - 1021

PMID: # 34122402  Garishah, FM.|Rother, N.|Riswari, SF.|Alisjahbana, B.|Overheul, GJ.|van Rij, RP.|van der Ven, A.|van der Vlag, J.|de Mast, Q.| et al. 2021. Front Immunol. 12: 629167.

PMID: # 30722079  Yu, X. et al. 2019. Thromb. Haemost. 119: 586-593.

PMID: # 31423724  Ferrière, S.|Kawecki, C.|Ottavi, JF.|Denis, CV.|Kauskot, A.|Christophe, OD.|Lenting, PJ.| et al. 2019. J Thromb Haemost. 17: 2035-2046.

PMID: # 30560697  Rigg, RA. et al. 2019. Platelets. 30: 126-135.

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 29785664  Zilberman-Rudenko, J.|Zhao, FZ.|Reitsma, SE.|Mitrugno, A.|Pang, J.|Shatzel, JJ.|Rick, B.|Tyrrell, C.|Hasan, W.|McCarty, OJT.|Schreiber, MA.| et al. 2018. Cardiovasc Eng Technol. 9: 515-527.

PMID: # 28083075  Zilberman-Rudenko, J.|Itakura, A.|Maddala, J.|Baker-Groberg, SM.|Vetter, R.|Tucker, EI.|Gruber, A.|Gerdes, C.|McCarty, OJ.| et al. 2016. Cell Mol Bioeng. 9: 496-508.

PMID: # 26725377  Zhu, S. et al. 2016. J. Thromb. Haemost. 14: 1070-81.

PMID: # 27816455  Streng, AS. et al. 2016. Biochem. Biophys. Res. Commun. 481: 165-168.

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

引用1 - 1021
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 8ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;