Molecular structure of (+)-Biotin 4-Amidobenzoic Acid, Sodium Salt, CAS Number: 102418-74-6
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt (CAS 102418-74-6)
Alternate Names:
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt is also known as Sodium N-(+)-biotinyl-4-aminobenzoate.
Application:
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt is a fluorogenic substrate for determination of Biotinidase activity.
CAS Number:
102418-74-6
Molecular Weight:
385.41
Molecular Formula:
C17H20N3NaO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt is a fluorogenic substrate for the determination of Biotinidase activity. It is hydrolyzed by biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin, an essential coenzyme for certain carboxylases, is used to modify histones and regulate gene transcription. (+)-Biotin 4-Amidobenzoic Acid, Sodium Salt releases 4-aminobenzoic acid (PABA) which is able to be quantified by either fluorescent or colorimetric methods. This technique is used in biotinidase activity assays to screen newborns for biotinidase deficiency.
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt (CAS 102418-74-6) References
- Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase. | Kobza, KA., et al. 2008. J Nutr Biochem. 19: 826-32. PMID: 18479898
- Biotin and biotinidase deficiency. | Zempleni, J., et al. 2008. Expert Rev Endocrinol Metab. 3: 715-724. PMID: 19727438
- Quantitative Analytical Method for the Determination of Biotinidase Activity in Dried Blood Spot Samples. | Szabó, E., et al. 2015. Anal Chem. 87: 10573-8. PMID: 26400555
- High-performance liquid chromatographic determination of lipoamidase (lipoyl-X hydrolase) activity with a novel substrate, lipoyl-6-aminoquinoline. | Yoshikawa, K., et al. 1996. J Chromatogr B Biomed Appl. 679: 41-7. PMID: 8998568
Substrate of:
Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt, 100 mg | sc-207358 | 100 mg | $332.00 | |||
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt, 250 mg | sc-207358A | 250 mg | $741.00 | |||
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt, 500 mg | sc-207358B | 500 mg | $1144.00 | |||
(+)-Biotin 4-Amidobenzoic Acid, Sodium Salt, 1 g | sc-207358C | 1 g | $1927.00 |