PKSI-527 CAS: 128837-71-8
MF: C25H31N3O4•HCl
MW: 473.99
A highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein.

PKSI-527 (CAS 128837-71-8)

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备用名: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
应用; PKSI-527 is a highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein
CAS号码: 128837-71-8
纯度: ≥95%
分子量: 473.99
分子式: C25H31N3O4•HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

PKSI-527 is a highly selective plasma kallikrein inhibitor (Ki = 0.81 μM) which can be used for affinity purification of kalikrein. It suppresses collagen-induced arthritis in a mouse model. Additionally, PKSI-527 has been shown to synergize with NO donors producing antithrombotic effects.


参考文献

1: K. Wanaka et al. Chem. Pharm. Bull. 1992 40 1814 2: M. Tada et al. Biol. Pharm. Bull. 2001 24 520 3: Y. Fujimori et al. Agents Actions 1993 39 42 4: H. Ikarugi et al. Thromb. Res. 2005 116 403

物理状态 :
Solid
溶解度 :
Soluble in water (5 mg/ml).
保存 :
Store at -20° C
Ki 数据 :
selective plasma kalikrein: Ki= 0.81 µM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C1CC(CCC1CN)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC(=O)O.Cl

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